Gene interactions and pathways from curated databases and text-mining

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PLK4 — TP53

Text-mined interactions from Literome

Naoe et al., Cancer Sci 2006 (Hematologic Neoplasms...) : Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking, centrosome duplication and regulation of p53
Bergstralh et al., Exp Cell Res 2007 (Lung Neoplasms) : Mass spectroscopy identified the protein as nucleophosmin/B23 (NPM), a multifunctional protein with diverse roles : ribosome biosynthesis, p53 regulation , nuclear-cytoplasmic shuttling, and centrosome duplication
Mantel et al., Blood 1999 (Polyploidy) : p53 has already been implicated in centrosome regulation