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SMAD1 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SMAD1 — TP53 (physical association, affinity chromatography technology) Chau et al., Nature communications 2012*

Text-mined interactions from Literome

Iwanaga et al., Cancer Res 2002 : Expression of mitotic spindle checkpoint protein hsMAD1 correlates with cellular proliferation and is activated by a gain-of-function p53 mutant ... The hsMad1 promoter was also activated preferentially by a gain-of-function p53 mutant ... Taken together, our results suggest that hsMAD1 might link p53 function to the generation of cellular aneuuploidy and that heightened activation of hsMad1 by gain-of-function p53 mutants could contribute to the worse prognosis of certain cancers
Wiegman et al., Radiother Oncol 2007 : However, as shown by the use of a specific inhibitor TGFbeta-1-receptor I-Smad signalling was not involved in this fast activation of ATM and p53