Gene interactions and pathways from curated databases and text-mining

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TNF — TNFRSF9

Text-mined interactions from Literome

Choi et al., Exp Mol Med 2005 : Cross linking of CD137 increased the secretion of IL-8 and TNF-alpha , promoted the expression of CD54 and CD11b, and increased adhesion to extracellular matrix ( ECM ) proteins
Zhang et al., J Immunol 2010 : The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-alpha and -beta
Hsieh et al., Am J Pathol 2010 : In a cell culture model of M cell differentiation, we found lymphotoxin/tumor necrosis factor alpha induction of CD137 ( TNFRSF9 ) protein on intestinal epithelial cell lines, raising the possibility that CD137 on M cells in vivo might interact with CD137L expressed by B cells
Kim et al., Immune network 2011 : We further demonstrated that JNK activation was required for TAT-CD137Lct induced production of TNF-a , while activation of Erk and p38 MAPK were involved in IL-6 and TNF-a production
Nagila et al., Virology journal 2013 : The p38 MAPK activation and TNF-a production were controlled by p38 MAPK and CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK, TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells