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TNF — TNFRSF9
Text-mined interactions from Literome
Choi et al., Exp Mol Med 2005
:
Cross linking of
CD137 increased the secretion of IL-8 and
TNF-alpha , promoted the expression of CD54 and CD11b, and increased adhesion to extracellular matrix ( ECM ) proteins
Zhang et al., J Immunol 2010
:
The expression of
CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and
induces secretion of
TNF-alpha and -beta
Hsieh et al., Am J Pathol 2010
:
In a cell culture model of M cell differentiation, we found
lymphotoxin/tumor necrosis factor alpha
induction of
CD137 ( TNFRSF9 ) protein on intestinal epithelial cell lines, raising the possibility that CD137 on M cells in vivo might interact with CD137L expressed by B cells
Kim et al., Immune network 2011
:
We further demonstrated that JNK activation was required for
TAT-CD137Lct induced production of
TNF-a , while activation of Erk and p38 MAPK were involved in IL-6 and TNF-a production
Nagila et al., Virology journal 2013
:
The p38 MAPK activation and
TNF-a production were
controlled by p38 MAPK and
CD137 signaling in DENV infected HepG2 cells as activated p38 MAPK, TNF-a and apoptosis were significantly decreased in p38 MAPK and CD137 depleted DENV infected HepG2 cells