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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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TNF — TP53

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: TP53 → TNF (increases)
    Evidence: J Leukoc Biol 2003 Mar 73(3) 363-8 (ResnetDB) An inhibitor of PKC, GF 109203X inhibited EGF-mediated suppression of TNF-alpha-induced accumulation of p53, p21 and induction of apoptosis. is translated to Activation of CDKN1A (Homo sapiens) Gene Expression by TNF (Homo sapiens) Protein
  • OpenBEL Selventa BEL large corpus: TP53 → TNF (increases) Rokhlin et al., Oncogene 2000*
    Evidence: TNF-alpha treatment resulted in accumulation of p53 in LNCaP and upregulation of p21/WAF1.
  • OpenBEL Selventa BEL large corpus: TP53 → TNF (increases)
    Evidence: We found that MnSOD protein expression and mRNA production were markedly enhanced after 4 h exposure to oxLDL, C2-ceramide, H2O2, or TNF-a (Fig. 1A, B). Similar results were obtained when p53 protein and mRNA levels of stimulated cells were analyzed (Fig. 2A, B)

Text-mined interactions from Literome

Yan et al., J Inflamm 1995 : In fact, only in the presence of Mg2+, but not in the absence of divalent cations or in the presence of Ca2+ alone, TNF increased p58c-fgr and p53/56lyn kinase activities ; and this was prevented by anti-CD18 antibodies
Holden et al., Med Hypotheses 1999 (Disease Progression...) : In addition, it has been established that tumor necrosis factor-alpha (TNF-alpha) can activate the expression of wild type p53 in concert with the nuclear transcription factor, NF-kappa B ... In this paper we shall advance the hypothesis that : ( i ) TNF-alpha indirectly controls immune surveillance ; and ( ii ) TNF-alpha controls DNA repair and tumor suppression through the regulation of wild type p53
Sayed et al., J Biol Chem 2000 : Furthermore, we demonstrate that anisomycin- and tumor necrosis factor-alpha induced phosphorylation of p53 at Ser-392, which is important for the transcriptional activity of this growth suppressor protein, requires p38 MAP kinase and CK2 activities
Rizvi et al., J Surg Res 2006 (Acute Disease...) : We hypothesized that TNF-alpha would induce IRF-1 and p53 protein binding in pancreatic acinar cells and that PYY would attenuate the effect
Chiarugi et al., Methods Mol Med 2001 : Each pathway is triggered by a different stimulus : growth factor default, irradiation, induction of the p53 oncosuppressor protein, glucocorticoid hormones ( in lymphocytes ), ligand binding to Fas/APO ( CD95 ), or tumor necrosis factor receptor (TNF-R) , perforin secreted by cytotoxic T cells ( reviewed by Hale et al. [ 1 ] )
Inagaki-Ohara et al., Oncogene 2001 : Interestingly, we found that injection of TNF readily induced IEC apoptosis and that radiation induced a p53 dependent increase in the intestinal level of TNF
Gualberto et al., Mol Cell Biol 1995 : Mutation of this sequence inhibited p53 transactivation and tumor necrosis factor inducibility of the human immunodeficiency virus type 1 long terminal repeat
Pastor et al., Dis Colon Rectum 2010 (Colorectal Neoplasms) : The purpose of the current study was to evaluate the effects of tumor necrosis factor alpha (TNF-alpha) on p53 and p53 up-regulated modulator of apoptosis ( PUMA ), a downstream effector of p53 in the apoptotic pathway in colorectal cancer cells ... TNF-alpha increased nuclear p53 expression in HT29 cells, which express p53 mutation, but not in HCT116 cells, which are wild type for p53
Saeed et al., Experimental biology and medicine (Maywood, N.J.) 2003 : Furthermore, the addition of AA to TNF-alpha treated proliferating endothelial cells blocked both the inhibition of retinoblastoma protein phosphorylation and enhanced p53 expression induced by TNF-alpha
Tsoporis et al., J Biol Chem 2008 (Inflammation) : These results demonstrate that S100A6 is induced by tumor necrosis factor-alpha via an NF-kappaB dependent mechanism, serving a role in homeostasis to limit tumor necrosis factor-alpha induced apoptosis by regulating p53 phosphorylation
Noman et al., Cell Immunol 2010 (Inflammation) : LPS induced tumor necrosis factor-alpha and interleukin-6 production was prevented by RIZ1 siRNA or a p53 pharmacological inhibitor
Saha et al., Environ Toxicol Pharmacol 2013 : Role of p53 mediated regulation of NF-?ß and TNF-a was elucidated by Western blot analysis
Hong et al., BMC molecular biology 2007 : Functionally, transiently overexpressed Zfra sequestered NF-kappaB ( p65 ), WOX1, p53 and phospho-ERK ( extracellular signal activated kinase ) in the cytoplasm, and TNF or UV light could not effectively induce nuclear translocation of these proteins
Manu et al., Int Immunopharmacol 2008 (Melanoma, Experimental) : All these results demonstrate that ursolic acid induce apoptosis via inhibition of NF-kappaB induced bcl-2 mediated anti-apoptotic pathway and subsequent activation of p53 mediated and TNF-alpha induced caspase-3 mediated pro-apoptotic pathways
Vadrot et al., PloS one 2012 (Carcinoma, Hepatocellular...) : Translocation of p53 to mitochondria was observed by Western Blot and co-immunoprecipitations showed that TNF-a induced p53 binding to GSK3ß and mitochondrial transcription factor A ( TFAM ) ... In addition, mitochondrial D-loop immunoprecipitation ( mtDIP ) revealed that TNF-a induced p53 binding to the regulatory D-loop region of mtDNA
Jeoung et al., J Biol Chem 1995 (Breast Neoplasms) : Taken together these results suggest that Rb, p53 , and Cip1 ( p21 ) proteins mediate TNF-alpha antimitogenic activity, and TNF-alpha induces growth arrest in the G1 phase in MCF-7 cells
Rojas et al., J Immunol 1999 : Anti-TNF-alpha inhibited apoptosis, diminished NO- production, p53 , and caspase 1 activation and increased Bcl-2 expression
Ladiwala et al., J Neurochem 1999 (Adenoviridae Infections) : p53 induction by tumor necrosis factor-alpha and involvement of p53 in cell death of human oligodendrocytes
Akca et al., Clin Chem Lab Med 2002 (Uterine Cervical Neoplasms) : Tumor necrosis factor-alpha induced accumulation of tumor suppressor protein p53 and cyclin dependent protein kinase inhibitory protein p21 is inhibited by insulin in ME-180S cells ... Since many tumors secrete growth factor ( s ) that inhibit apoptosis and support the growth of cancer cells, we wanted to know whether insulin would have an effect on antitumor and p53 inducing activities of human tumor necrosis factor-alpha (TNF-alpha) ... Here we show that treatment of human cervical carcinoma cell line, ME-180S, with TNF-alpha results in time dependent accumulation of p53 and its transcriptional target, p21
Wheelhouse et al., Int J Mol Med 2003 : This study was carried out to determine if TNF-alpha caused oxidative DNA damage in primary cultures of murine hepatocytes and whether any damage would result in the induction of the tumor suppressor p53 and cell-cycle arrest
Ros et al., Hepatology 2001 (Carcinoma, Hepatocellular...) : Because p53 is up-regulated by TNF-alpha in an NF-kappaB dependent manner and the Mdr1b promoter contains a p53 binding site, we used liver cells expressing a dominant negative p53 to show that TNF-alpha up-regulation of Mdr1b is independent of functional p53
Wang et al., Clin Cancer Res 2005 (Breast Neoplasms...) : Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted TNF-alpha induced stability of p53, up-regulation of phospho-p53ser15 , p21waf/cip, and Bax, and down-regulation of Bcl-2 and Bcl-xL, which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing
Son et al., PloS one 2012 (Ovarian Neoplasms) : Transient transfection of p53 into p53-null ovarian cancer cells downregulated proinflammatory chemokines induced by tumor necrosis factor-a (TNF) , a proinflammatory cytokine abundantly expressed in ovarian cancer
Doman et al., J Interferon Cytokine Res 1999 : TNF also stimulated p53 , p21WAF1, and Bax accumulation with subsequent PARP cleavage and nucleosomal DNA laddering in MCF-7 cells but did not stimulate these processes in MCF-7/3E9 cells
Akca et al., Growth Factors 2003 (Uterine Cervical Neoplasms) : Since many tumors secrete growth factor ( s ) that inhibit apoptosis and support the growth of cancer cells, we investigated the effects of human epidermal growth factor (EGF) on human TNF-alpha mediated induction of p53 and its transcriptional target, p21 in TNF-alpha sensitive human cervical carcinoma cell line, ME180S ... We found that TNF-alpha can increase the cellular levels of p53 , p21 and induce apoptosis in ME180S cells ... An inhibitor of PKC, GF 109203X inhibited EGF mediated suppression of TNF-alpha induced accumulation of p53 , p21 and induction of apoptosis
Rastogi et al., Cell Death Differ 2012 : Stimulation of HAECs with TNF-a led to an increased expression of p73 protein and a reduction in the levels of p53
Li et al., Cell Mol Immunol 2010 : Effects of NS1 variants of H5N1 influenza virus on interferon induction, TNFalpha response and p53 activity ... We examined the effects of these mutations on interferon ( IFN ) induction, tumor-necrosis factor (TNF)alpha response , p53 activity and apoptosis
Yeung et al., J Biol Chem 1998 : By reverse transcription-polymerase chain reaction, we demonstrated that TNF-alpha transiently induces the tumor suppressor p53 in U937 cells
Kim et al., Carcinogenesis 2002 : TNF-alpha potentiated the cadmium induced accumulation of p53 but did not affect expression levels of Bax, Mdm2 and p21 ( WAF/CIP )
Saile et al., Eur J Cell Biol 2001 : By suppressing spontaneous apoptosis TGF-beta as well as TNF-alpha inhibited p53 gene expression while that of the p21WAF1 gene was increased
Yin et al., Neurosurgery 1995 (Brain Neoplasms...) : The results of immunoblotting assay demonstrated that TNF-alpha decreased the expression of mutant p53 protein but induced the expression of wild-type p53 in C6 cells during apoptosis
Kim et al., Apoptosis 2002 : Calpeptin suppresses tumor necrosis factor-alpha induced death and accumulation of p53 in L929 mouse sarcoma cells ... In this report, we show a novel suppressive effect of calpeptin, a calpain inhibitor, on TNFalpha induced cell death and accumulation of p53 in L929 mouse fibrosarcoma ... Preincubation of cells with calpeptin blocked both TNFalpha induced cell death and accumulation of p53 as examined with Western blot ... TNFalpha induced accumulation of p53 was in part contributed by increase of p53 mRNA level ( 2.2-fold ) in a calpeptin-insensitive manner ... Taken together, our findings suggest that TNFalpha induces calpeptin dependent, but calpain independent accumulation of p53 protein as a necessary step leading to death in L929 cells
Menon et al., J Assist Reprod Genet 2002 : TNF also increased p53 levels in the tissues ( 0.05 ng/mL ) compared with control cultures ( 0.03 ng/mL ; p = 0.02 ) ... TNF increases proapoptotic p53 levels and caspase activities in fetal membranes
Muret et al., Ann Oncol 2008 (Sarcoma) : The relationship between p53 status and response to TNF-alpha and melphalan in patients undergoing ILP is unknown
Yarosh et al., Photodermatol Photoimmunol Photomed 2000 : This implies that p53 directly or indirectly represses TNFalpha gene expression and that modification of p53 mRNA stability or phosphorylation of p53 protein after UV may be responsible for TNFalpha induction in the membrane
Wu et al., J Biol Chem 1994 : Both p65 transactivation and TNF-alpha induction of the p53 promoter depended on an intact NF-kappa B site
Gualberto et al., J Biol Chem 1995 : We have recently reported that the p53 tumor suppressor gene product binds to a site within the Sp1 binding region of the HIV-1 LTR and contributes to the TNF induction of this promoter ... Importantly, TNF induced the association between p53 and Sp1 in Jurkat T cells
Donato et al., J Biol Chem 1998 : TNF induced changes in p53 levels were detected 1 h after treatment, and peak levels were measurable 4-8 h after TNF exposure
Piguet et al., Eur J Immunol 1998 : TNF induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53 ... TNF increased the expression of p53 tumor suppressor gene in the enterocytes from the crypts but not from the villi, as seen by Western blots and histochemistry ... TNF increased the expression of p53 in both TNFR2-/- and TNFR1-/- mice
Brown et al., EMBO J 2007 : We also demonstrate that TNF-alpha is upregulated in response to p53 and p53 inducing genotoxic stress, in a CDIP dependent manner
López-Marure et al., Eur J Biochem 2000 : When the responses of the tumour suppressors p53 and RB were analysed, it was found that TNF-alpha and C8-ceramide induced increased expression of p53
Gotlieb et al., Am J Obstet Gynecol 1994 (Ovarian Neoplasms) : Tumor necrosis factor-alpha induced a significant up-regulation of p53 messenger ribonucleic acid levels in ovarian cancer cells grown in nude mice and in vitro, whereas interleukin-6 did not ... Tumor necrosis factor-alpha induced up-regulation of p53 tumor suppressor gene expression in epithelial ovarian cancer cell lines, together with the induction of cell death by apoptosis