Gene interactions and pathways from curated databases and text-mining

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TP53 — TP53

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Radhakrishnan et al., Oncogene 2008 : Tumor suppressor p53 is stabilized in response to gamma-irradiation or treatment with DNA damaging agents, and as a result p53 transcriptionally activates its targets leading to cell-cycle arrest or apoptosis
Yamakuchi et al., Cell cycle (Georgetown, Tex.) 2009 (Neoplasms) : The TP53 is one of the most commonly mutated genes in human cancers, and its gene product p53 activates transcription of a set of miRNA including the miR-34 family of miRNA
Zhu et al., Chin J Cancer 2003 : When expression of p53 elevated, p53-mdm2 and p14(ARF)-mdm2 feedback loops can accurately regulate the expression level of p53 , and the cooperation of p33ING1b gene is also needed in the process of p53 exerting normal function
Marcel et al., Cell Death Differ 2012 : In response to stress, p53 binds and transactivates the internal TP53 promoter, thus regulating the expression of its own isoform, d133p53a
Willers et al., Carcinogenesis 2001 : We and others reported previously that the tumor suppressor p53 down-regulates spontaneous homologous recombination in chromosomally integrating plasmid substrates, but how p53 affects homology dependent repair of DNA double-strand breaks has not been established
Porté et al., J Biol Chem 2009 : Tumor suppressor p53 regulates the expression of p53 induced genes (PIG) that trigger apoptosis
Blasenbreu et al., Verh Dtsch Ges Pathol 1998 (Bone Neoplasms...) : Now we tried to find out, whether p53-accumulation is caused by TP53-aberrations or functional inactivation of p53-wildtype protein by MDM2
Itoh et al., Mol Cell Biol 2003 (Xeroderma Pigmentosum) : Impaired regulation of tumor suppressor p53 caused by mutations in the xeroderma pigmentosum DDB2 gene : mutual regulatory interactions between p48 ( DDB2 ) and p53
Lee et al., Biochemistry 2009 : Molecular interactions between the tumor suppressor p53 and the transcriptional coactivators CBP/p300 are critical for the regulation of p53 transactivation and stability
Eckardt-Michel et al., J Virol 2008 : F protein expression in epithelial cells caused phosphorylation of tumor suppressor p53 at serine 15, activation of p53 transcriptional activity, and conformational activation of proapoptotic Bax