◀ Back to MMP11

ACAN — MMP11

Text-mined interactions from Literome

Tortorella et al., Osteoarthritis Cartilage 2001 : ( 3 ) Both constitutive and stimulated cleavage of aggrecan at the ADAM-TS4 and ADAM-TS5-sensitive sites in cartilage was blocked by a general metalloproteinase inhibitor but not by a MMP-specific inhibitor, and this inhibition correlated with inhibition of aggrecan release from cartilage
Pratta et al., J Biol Chem 2003 : A selective MMP inhibitor did not block aggrecan degradation but caused complete inhibition of collagen breakdown
Karsdal et al., Arthritis Res Ther 2008 : After induction of MMP mediated aggrecan and collagen type II degradation, the chondrocytes had impaired repair capacity
Eltawil et al., Osteoarthritis Cartilage 2009 (Arthritis, Experimental...) : Compared to C57BL/6, DBA/1 mice displayed a progressive decline of chondrocyte apoptosis, cell proliferation within the repair tissue, persistent type II collagen neo-deposition, less type II collagen degradation, less aggrecanases and more MMP induced aggrecan degradation
Jackson et al., Arthritis Rheum 2009 (Disease Models, Animal...) : APC stimulated aggrecan and collagen breakdown were due to MMP activity but were not associated with modulation of MMP, ADAMTS, or TIMP expression
Madsen et al., Biomarkers 2010 (Osteoarthritis) : In contrast, MMP mediated aggrecan degradation began only at day 16 and continued to day 21
latridis et al., Spine (Phila Pa 1976) 2011 : The shift from aggrecanase to MMP induced degradation products with dynamic compression overloading suggests that protein degradation and loss can precede major structural disruption in the IVD, and that MMP induced aggrecan degradation may be a marker of mechanically induced disc degeneration
Durigova et al., Matrix Biol 2011 : The analysis of aggrecan IGD degradation in bovine articular cartilage explants treated with catabolic cytokines over a 19-day period showed that MMP mediated degradation of aggrecan within the IGD can only be observed following day 12 of culture
Boeuf et al., European cells & materials 2012 : In contrast, MMP induced cleavage of aggrecan appeared at 14 d after induction of chondrogenesis ... Submission of differentiated MSC pellets to IL1ß treatment for 3 d resulted in strong upregulation of ADAMTS1, 4 and 5, rapid proteoglycan depletion, and stimulation of ADAMTS induced but not MMP induced cleavage of aggrecan
Bottomley et al., Biochem J 1997 : Matrix metalloproteinase ( MMP ) inhibitors inhibited aggrecan loss from bovine nasal explants incubated in the presence of recombinant human interleukin 1alpha