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ADAMTS10 — TIMP1
Text-mined interactions from Literome
Lee et al., Arthritis Rheum 2005
(Wounds and Injuries) :
Matrix molecules showed little change in expression after injurious compression, whereas MMP-3 increased approximately 250-fold,
ADAMTS-5 increased approximately 40-fold, and
tissue inhibitor of metalloproteinases 1 increased approximately 12-fold above the levels in free swelling cultures
Johnston et al., J Hand Surg Am 2007
(Dupuytren Contracture) :
This study measured the expression of all MMP,
ADAMTS , and TIMP genes in DD. Contraction and fibrosis may result from : ( 1 ) increased collagen biosynthesis mediated by increased ADAMTS-14 ; ( 2 ) an increased level of
TIMP-1 blocking MMP-1- and MMP-13 mediated collagenolysis ; and ( 3 ) contraction enabled by MMP-14 mediated pericellular collagenolysis ( and potentially MMP-7 ), which may escape inhibition by TIMP-1