Gene interactions and pathways from curated databases and text-mining

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ADAMTS10 — TIMP1

Text-mined interactions from Literome

Lee et al., Arthritis Rheum 2005 (Wounds and Injuries) : Matrix molecules showed little change in expression after injurious compression, whereas MMP-3 increased approximately 250-fold, ADAMTS-5 increased approximately 40-fold, and tissue inhibitor of metalloproteinases 1 increased approximately 12-fold above the levels in free swelling cultures
Johnston et al., J Hand Surg Am 2007 (Dupuytren Contracture) : This study measured the expression of all MMP, ADAMTS , and TIMP genes in DD. Contraction and fibrosis may result from : ( 1 ) increased collagen biosynthesis mediated by increased ADAMTS-14 ; ( 2 ) an increased level of TIMP-1 blocking MMP-1- and MMP-13 mediated collagenolysis ; and ( 3 ) contraction enabled by MMP-14 mediated pericellular collagenolysis ( and potentially MMP-7 ), which may escape inhibition by TIMP-1