Gene interactions and pathways from curated databases and text-mining

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ADCY6 — IL1B

Text-mined interactions from Literome

Zhou et al., Biochim Biophys Acta 2005 : Since adenylate cyclase activator forskolin prevents the increase in NE-induced IL-1beta and IL-10, the up-regulatory effect of NE on those cytokines appears to be mediated, at least in part, by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels
Rodan et al., J Immunol 1990 (Bone Resorption...) : Although IL-1 had no effect on PGE2 synthesis, both IL-1 alpha and IL-1 beta enhanced PGE2 stimulation of adenylate cyclase two- to four-fold in a dose dependent manner
Schettini et al., Biochem Biophys Res Commun 1988 (Second Messenger Systems) : In the present study we evaluated the effect of interleukin 1-beta on adenylate cyclase activity in 235-1 pituitary cell line ... The inhibitory effect of interleukin 1 beta on adenylate cyclase activity disappeared, while the highest concentration of interleukin 1 beta tested, caused a meaningful stimulation of adenylate cyclase activity which is not present in acute condition