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AKT1 — GNA13
Text-mined interactions from Literome
Wu et al., FEBS J 2006
:
Finally, overexpression of the dominant negative mutant of RhoA blocked G alpha12QL- and G alpha13QL mediated inhibition, suggesting that activated G alpha12 and
G alpha13 inhibit
Akt signaling via RhoA ... Collectively, this study demonstrated the inhibitory
effect of activated G alpha11, G alpha14, G alpha16, G alpha12 and
G alpha13 on pro-survival
Akt signaling
Chen et al., J Nat Med 2012
(Brain Neoplasms...) :
The pro-apoptotic effect of GNA on U251 cells was shown to be mediated through inactivation of the Akt pathway, because
GNA efficiently suppressed the expression level of EGFR and
reduced the phosphorylation of
Akt ( T308 ) and GSK3ß ( S9 )