Gene interactions and pathways from curated databases and text-mining

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AKT2 — NOX4

Text-mined interactions from Literome

Cui et al., Inflamm Res 2000 : These results suggest that the formation of F-actin is dependent on PI3-K and independent of PKC, ERK and p38 MAPK as well as the increase in intracellular Ca2+, whereas the activation of NADPH oxidase is partly dependent on ERK, p38 MAPK, Akt regulated by PI3-K, and strongly dependent on the activation of PKC and the increase in intracellular Ca2+
Herkert et al., Circulation 2002 : Furthermore, thrombin stimulated the phosphorylation of the PI 3-kinase target protein kinase B/Akt in a redox-sensitive and NADPH oxidase dependent manner
Hoyal et al., Proc Natl Acad Sci U S A 2003 : Modulation of p47PHOX activity by site-specific phosphorylation : Akt dependent activation of the NADPH oxidase
Gorin et al., American journal of physiology. Renal physiology 2003 : Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells
Touyz et al., Arterioscler Thromb Vasc Biol 2005 : The p47phox : actin interaction, through cortactin, plays an important role in Ang II-mediated site directed assembly of functionally active NAD ( P ) H oxidase , ROS generation, and activation of redox-sensitive p38MAP kinase and Akt , but not ERK1/2
Xia et al., Hum Gene Ther 2004 (Brain Ischemia...) : Enhanced cell survival after AM gene transfer was accompanied by markedly increased cerebral nitric oxide and Bcl-2 levels, as well as Akt and GSK-3beta phosphorylation, but reduced NADPH oxidase activity and superoxide production
Block et al., J Biol Chem 2007 : Down-regulation of Nox1, Nox4 , and p22phox expression by small interfering RNA also decreased HIF-2alpha protein expression and inhibited Akt and 4E-BP1 phosphorylation, suggesting that a translational mechanism is involved in maintaining HIF-2alpha in VHL-deficient cells
Chen et al., Am J Physiol Heart Circ Physiol 2007 (Anoxia...) : Our findings underscore the important role of NADPH oxidase and its subunit p47(phox) in modulating Akt and ERK1/2 activation, angiogenic growth factor expression, and angiogenesis in myocardium undergoing I/R
Roy et al., Arch Biochem Biophys 2007 : NADPH oxidase inhibitor, DPI ( Diphenyl iodide ), and pharmacological inhibitor of Akt, Akt inhibitor IV, also showed a reduction in MDR1 expression, although not to the same extent as C-PC mediated inhibition of MDR1 expression
Govindarajan et al., J Clin Invest 2007 (Cell Transformation, Neoplastic...) : Second, Akt can induce expression of the ROS generating enzyme NOX4
Abid et al., J Biol Chem 2007 : The permissive role of NADPH oxidase on phosphoinositide 3-kinase-Akt-forkhead signaling is mediated at post-VEGF receptor levels and involves the nonreceptor tyrosine kinase Src
Stebbins et al., J Cardiovasc Pharmacol Ther 2008 : Vascular endothelial growth factor induced activation of Akt increased NOx in treated ( 50 nM DHA ) versus untreated HCAEC ( 9.2 +/- 1.0 vs 3.3 +/- 1.1 micromol/microg protein/microL )
De Minicis et al., Hepatology 2008 (Disease Models, Animal...) : Leptin induced phosphorylation of extracellular signal regulated kinase ( ERK ) and AKT , but not of STAT3, was blocked by NADPH oxidase inhibition
Csibi et al., PloS one 2010 : Inhibition of nitric oxide synthase and NAD ( P ) Hoxidase and scavenging of free radicals with myricetin restored insulin stimulated Akt phosphorylation and GLUT4 translocation in the presence of Ang II
Park et al., J Mol Med (Berl) 2010 : Inhibitors of p38 MAPK and Akt , but not of Erk, reduced radiation induced fibroblast differentiation and Nox4 expression
Schreiner et al., Cardiovasc Res 2011 : A small interfering RNA mediated knock-down of Nox4 showed that Nox4 was not required for Ang II- or EGF induced Akt phosphorylation
Chern et al., Planta Med 2011 (Cerebral Infarction...) : Andrographolide inhibits PI3K/AKT dependent NOX2 and iNOS expression protecting mice against hypoxia/ischemia induced oxidative brain injury
Barale et al., Stem Cells Dev 2012 : High glucose via NOX dependent ROS generation and AKT activity promotes adipose derived stem cell de-differentiation ... Thereby, our data indicate that HG via NOX dependent Akt activity induces ASC de-differentiation, and suggest that HG pre conditioning might be exploited for ASC ex-vivo expansion
Huang et al., Free Radic Biol Med 2012 (Carcinoma...) : Accordingly, we suggest that PI3K/AKT signaling mediates TGIF induced Nox2/p67(phox) complex activation and the resultant superoxide production which reinforces the PI3K/AKT signaling to promote the cellular migration/invasion ability of UC
Wang et al., Toxicological sciences : an official journal of the Society of Toxicology 2012 (Colonic Neoplasms) : These responses are related to intracellular reactive oxygen species ( ROS ) generation, NADPH oxidase activation , and upregulation of PI3K/Akt and hypoxia-inducible factor 1 alpha ( HIF-1a ) signaling
Yang et al., PloS one 2013 : The AGEs stimulated Akt activation was blocked by a PI3-kinase inhibitor LY 294002, Src inhibitor PP2, an antioxidant NAC, superoxide scavenger Tiron, or nicotinamide adenine dinucleotide phosphate ( NAD ( P ) H ) oxidase inhibitor DPI, suggesting the involvement of Src and NAD ( P ) H oxidase in the activation of PI3-kinase-Akt pathway by AGEs