Gene interactions and pathways from curated databases and text-mining

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AKT3 — CXCL10

Text-mined interactions from Literome

Liu et al., J Virol 2005 : Akt/protein kinase B activation by adenovirus vectors contributes to NFkappaB dependent CXCL10 expression ... The effect of Akt on CXCL10 mRNA expression occurred via NFkappaB dependent transcriptional activation, since AktAAA overexpression and Ly294002 both inhibited CXCL10 and NFkappaB promoter activation in luciferase reporter experiments ... These results show that Akt plays a role in the Ad vector activation of NFkappaB and CXCL10 expression
Proost et al., Arthritis Res Ther 2006 (Autoimmune Diseases...) : In contrast to intact CXCL10, NH2-terminally truncated CXCL10 ( 3-77 ) did not induce extracellular signal regulated kinase 1/2 or Akt/protein kinase B phosphorylation in CXC chemokine receptor 3-transfected cells
Sai et al., J Biol Chem 2006 : Although both mutant and wild-type receptors could mediate Akt and Erk activation in response to CXCL8 , the level of activation of these two kinases was much lower in the cell line expressing the mutant receptors
Brkovic et al., J Leukoc Biol 2007 : Finally, both angiopoietins showed a synergistic effect on the induction of Akt phosphorylation mediated by CXCL8/IL-8
Poggi et al., Curr Med Chem 2007 (Autoimmune Diseases...) : IP-10/CXCL10 and SDF-1/CXCL12 induced transmigration are phosphoinositide-3 kinase (PI-3K) and Akt/PKB dependent
Petrai et al., Int J Biochem Cell Biol 2008 : In cells expressing CXCR3-A, CXCL10 ( IP-10 ) at nanomolar concentrations induced activation of ERK, Akt , and Src, as previously described in human vascular pericytes ... In cells expressing CXCR3-A, CXCL10 ( IP-10 ) at nanomolar concentrations induced activation of ERK, Akt , and Src, as previously described in human vascular pericytes
Schulthess et al., Cell Metab 2009 (Diabetes Mellitus) : CXCL10 induced sustained activation of Akt , JNK, and cleavage of p21 activated protein kinase 2 (PAK-2), switching Akt signals from proliferation to apoptosis
Korniejewska et al., Immunology 2011 : We report that CXCL4 induces intracellular calcium mobilization as well as Akt and p44/p42 extracellular signal regulated kinase phosphorylation, in activated human T lymphocytes
Lin et al., J Biol Chem 2011 : In this study, we further investigated the roles of Rac1, phosphoinositide 3-kinase (PI3K), and Akt in thrombin induced NF-?B activation and IL-8/CXCL8 expression