Gene interactions and pathways from curated databases and text-mining

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ALOX5 — CD36

Text-mined interactions from Literome

Yun et al., Free Radic Biol Med 2009 (Atherosclerosis) : This study investigated the role of 5-LO in HNE induced CD36 expression and macrophage foam cell formation, and the link between HNE and 5-LO ... In peritoneal macrophages from 5-LO-deficient mice, HNE induced CD36 expression was markedly attenuated, confirming a pivotal role of 5-LO in HNE induced CD36 expression ... Collectively, these data suggest that p38 MAPK mediated activation of 5-LO by HNE might enhance CD36 expression, consequently leading to the formation of macrophage foam cells
Yun et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2009 : In addition, HNE enhanced expression of CD36 was reduced by these inhibitors, which indicated a role for NADPH oxidase and 5-LO on CD36 expression