◀ Back to RHOA
APOB — RHOA
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
APOB
→
RHOA
(increases, APOB Activity)
Evidence: pitavastatin, a novel HMG Co-A reductase inhibitor, was found to inhibit the expression of apoB48 receptor via inhibition of RhoA. In fact, pretreatment of THP-1 macrophage significantly reduced RLP-induced foam cell formation...
Text-mined interactions from Literome
Zhu et al., Biochim Biophys Acta 2003
:
In revealing the mechanism underlying the translocation of eNOS, we found that a high level of
LDL increased the level of membrane associated and GTP formed
RhoA and activated the RhoA downstream kinase ROCK-1 activity
Sugimoto et al., Cardiovasc Res 2009
:
This study was conducted to investigate the role of the LOX-1-MT1-MMP axis in
RhoA and Rac1 activation in
response to
ox-LDL in ECs ...
Ox-LDL induced rapid
RhoA and Rac1 activation as well as MT1-MMP activity in cultured human aortic ECs ... Inhibition of LOX-1 prevented
ox-LDL dependent
RhoA and Rac1 activation ... Knockdown of MT1-MMP by small interfering RNA prevented
ox-LDL induced
RhoA and Rac1 activation, indicating that MT1-MMP is upstream of RhoA and Rac1