Gene interactions and pathways from curated databases and text-mining

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APOE — CASP4

Text-mined interactions from Literome

Date et al., J Mol Cell Cardiol 2003 (Anoxia...) : Z-IETD.fmk and Z-LEHD.fmk, selective inhibitors for caspases 8 and 9, respectively, abolished caspase 3 activation induced by Ad2/nchFasL or H/R. Z-IETD.fmk also significantly reduced Ad2/nchFasL- or H/R induced cardiomyocyte death
Mihovilovic et al., J Lipid Res 2007 : On HFD, both apoE3-VLDL and apoE4-VLDL ( HFD VLDL ) inhibit caspase 3/7 activation initiated by serum withdrawal