Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
AR
→
STAT3
(directlyIncreases, STAT3 Activity, AR Activity)
Ueda et al., J Biol Chem 2002* Evidence: Immunoprecipitation and transactivation studies showed a direct interaction between amino acids 234-558 of the AR NTD and STAT3 following IL-6 treatment of LNCaP cells. These results demonstrate that activation of the human AR NTD by IL-6 was mediated through MAPK and STAT3 signal transduction pathways in LNCaP prostate cancer cells.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *