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ARF5 — E2F5

Text-mined interactions from Literome

Parisi et al., Biochem Biophys Res Commun 2002 : Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2 , E2F3, and Sp1-like factors ... Moreover, our data suggest that the ARF promoter is regulated by E2F through both direct binding to the promoter sequences and indirectly, probably by being tethered to the ARF promoter by Sp1-like factors
Mason et al., Oncogene 2002 (Bone Neoplasms...) : p14(ARF) regulates E2F activity ... p14(ARF) regulates E2F activity in different cell-types, including p53 ( -/- ) /mdm ( -/- ) MEFs, thus excluding that the effects of p14(ARF) are indirectly caused through MDM2 modulation
Aslanian et al., Genes Dev 2004 (Cell Transformation, Neoplastic) : Our data also demonstrate a direct role for E2F in the oncogenic activation of Arf ... Thus, distinct E2F complexes directly contribute to the normal repression and oncogenic activation of Arf
Komori et al., EMBO J 2005 : The tumor suppressor p14(ARF) gene is induced by ectopically expressed E2F , a positive regulator of the cell cycle ... How p14(ARF) gene is regulated by E2F in normally growing cells and tumor cells remains obscure ... Here we show that regulation of p14(ARF) gene by E2F is distinct from that of classical E2F targets
Rizos et al., Cell cycle (Georgetown, Tex.) 2007 (Genetic Predisposition to Disease) : In this report we explored the effects of ARF on E2F ubiquitination and degradation in relationship to cell cycle effects and p53 status
Zhang et al., J Cell Biochem 2010 : Thus, E2F mediated activation of the ARF gene and ARF mediated functional inhibition of E2F compose a feedback loop, by which the two opposites act in concert to regulate cell proliferation and apoptosis, depending on the cellular context and the environment