Gene interactions and pathways from curated databases and text-mining

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ATF5 — CASP9

Text-mined interactions from Literome

Lin et al., Anticancer Res 2007 (Nasopharyngeal Neoplasms) : Moreover, for the first time in NPC cells it was demonstrated that the pathway involved in rhein induced apoptosis is caspase dependent, presumably through the endoplasmic reticulum ( ER ) stress pathway, as shown by an increase in the levels of glucose regulated protein 78 (GRP 78), PKR-like ER kinase (PERK), activating transcription factor 6 ( A TF6 ) and CCAA TIenhancer binding protein homologous protein ( CHOP ) as well as the activation of caspase-3 , -8, -9 and -12
Liu et al., J Biol Chem 2012 (Carcinoma, Hepatocellular...) : Nucleophosmin ( NPM1/B23 ) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase dependent ATF5 degradation in hepatocellular carcinoma cells