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ATP5O — PLA2G1B

Text-mined interactions from Literome

Chan et al., Neurochem Int 1987 : PLA(2) inhibited ( Na ( + ) + K ( + ) ) -ATPase but was not effective on p-nitrophenyl-phosphatase activity whereas PLC stimulated both enzymes
Hussain et al., Clin Exp Hypertens 1996 : The present study was designed to evaluate the role of phospholipase A2 (PLA2) and its metabolic pathway in dopamine induced inhibition of Na+, K ( + ) -ATPase in renal proximal tubules from Wistar-Kyoto ( WKY ) rats and spontaneously hypertensive rats ( SHR ) ... Dopamine inhibited Na+, K ( + ) -ATPase activity in a concentration ( 1 nM-10 microM ) -dependent manner in WKY rats while it failed to inhibit the enzyme activity in SHR. Dopamine ( 10 microM ) -induced inhibition of Na+, K ( + ) -ATPase activity in WKY rats was significantly blocked by mepacrine ( 10 microM ), a PLA2 inhibitor, suggesting the involvement of PLA2 in dopamine mediated inhibition of Na+, K ( + ) -ATPase ... These data suggest that PLA2 is involved in dopamine induced inhibition of Na+, K ( + ) -ATPase and altered arachidonic acid metabolism may contribute to reduced dopaminergic inhibition of Na+, K ( + ) -ATPase activity in spontaneously hypertensive rats
Hussain et al., Clin Exp Hypertens 1997 (Hypertension) : This report will ( i ) review the coupling of DA1 receptor with G proteins and their levels in Wistar Kyoto ( WKY ) rats and SHR and ( ii ) discuss studies dealing with the role of PLA2 in dopamine induced inhibition of Na+, K ( + ) -ATPase in WKY rat and SHR kidneys ... Dopamine inhibited Na+, K ( + ) -ATPase activity in a concentration ( 10 ( -9 ) -10 ( -5 ) M ) -dependent manner in WKY rats while it failed to inhibit the enzyme activity in SHR. Dopamine ( 10 microM ) -induced inhibition in Na+, K ( + ) -ATPase activity was significantly blocked by mepacrine ( a PLA2 inhibitor ) suggesting the involvement of PLA2 in dopamine mediated inhibition of Na+, K ( + ) -ATPase