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BCR — PPP2CA
Text-mined interactions from Literome
Neviani et al., Cancer Cell 2005
(Blast Crisis...) :
In imatinib-sensitive and -resistant ( T315I included ) BCR/ABL+ cell lines and CML-BC progenitors, molecular and/or pharmacological activation of
PP2A promotes dephosphorylation of key regulators of cell proliferation and survival,
suppresses BCR/ABL activity, and induces BCR/ABL degradation
Hu et al., PloS one 2009
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
While exerting suppressive effects on
BCR-ABL , E2F1, and beta-catenin, IM/BOR and IM/PSI
inhibited proteasomal degradation of protein
phosphatase 2A (PP2A) , leading to a re-activation of this important negative regulator of BCR-ABL