Gene interactions and pathways from curated databases and text-mining

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BDNF — CASP3

Text-mined interactions from Literome

Kurokawa et al., Invest Ophthalmol Vis Sci 1999 (Reperfusion Injury) : BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia
Han et al., Neurobiol Dis 2000 (Brain Ischemia...) : BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia ... Utilizing a specific molecular marker of an apoptotic pathway, these findings demonstrate that H-I injury to the developing brain is a strong apoptotic stimulus leading to caspase-3 activation, that BDNF can block this process in vivo, and that the ability of BDNF to inhibit caspase activation and subsequent apoptosis likely accounts in large part for its protection against neuronal injury in this model
Klöcker et al., J Neurosci 2000 (MAP Kinase Signaling System) : Furthermore, we provide evidence that BDNF suppresses cleavage and enzymatic activity of the neuronal cell death effector caspase-3
Ukai et al., J Neural Transm 2004 : Moreover, brain derived neurotrophic factor (BDNF) reduced the caspase-3 activity and protected neurons from haloperidol induced apoptosis
Bifrare et al., J Infect Dis 2005 (Disease Models, Animal...) : Brain derived neurotrophic factor (BDNF) blocks activation of caspase-3 , reduces translocation of apoptosis inducing factor ( AIF ), attenuates excitotoxicity of glutamate, and increases antioxidant enzyme activities
Pérez-Navarro et al., J Neurochem 2005 : Brain derived neurotrophic factor prevents changes in Bcl-2 family members and caspase-3 activation induced by excitotoxicity in the striatum
Zhang et al., Brain Res 2006 (Brain Ischemia...) : This combination could also significantly ameliorate DWI of MRI and behavior examination results, and promote the expression of BDNF and inhibit the expression of caspase-3
Zhao et al., Neurosci Lett 2009 : Furthermore, inactivating BDNF also attenuated the suppression by ASC-CM of glutamate induced caspase-3 activity, but not p38 phosphorylation
Cao et al., Brain Res Bull 2011 (Brain Ischemia...) : Further investigation demonstrated that treatment with baicalin remarkably promoted the expression of BDNF and inhibited the expression of caspase-3 at mRNA and protein levels by real-time RT-PCR and Western blot, respectively