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BECN1 — CAPN12

Text-mined interactions from Literome

Yoo et al., J Biol Chem 2010 (Cell Transformation, Neoplastic...) : We also found that ras activates a GTPase RhoA, that RhoA promotes activation of a protease calpain , and that calpain triggers degradation of Beclin-1 , a critical mediator of autophagy, in these cells
Russo et al., Cell death & disease 2011 (Disease Models, Animal...) : Altogether, our results provide original evidence for calpain mediated cleavage of Beclin-1 and deregulation of basal autophagy in the rat retina that has undergone ocular ischemia/reperfusion injury
Cheng et al., PloS one 2012 (Brain Neoplasms...) : The decrease in Beclin 1 following TMZ-Se treatment were rescued by the calpain inhibitors and the calpain mediated degradation of Beclin1 had no effect on autophagy but promoted apoptosis in cells treated with TMZ-Se
You et al., Mol Cell Biochem 2013 (Melanoma) : In contrast, calpain inhibitor could not prevent the cleavage of either Beclin-1 or Atg5, and was unable to prevent cell death