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BLM — CTNND1

Text-mined interactions from Literome

Bolzán et al., Mutat Res 2002 : A strong inhibitory effect ( around 80 % ) of rIFN-alpha-2a on the yield of BLM induced CAs in the G(2) phase of the cell cycle was also observed ... It is suggested that the inhibitory effect of rIFN-alpha-2a on the induction of CAs by BLM is mainly due to the stimulation of DNA synthesis and repair by the cytokine
Laczmanska et al., Environ Mol Mutagen 2007 (Chromosome Aberrations) : The frequency of bleomycin (BLM) induced CAs is an indirect measure of the effectiveness of DNA repair mechanisms, and a predictor of environment related risk of cancer ... The aim of the study was to elucidate whether the frequency of BLM induced CAs is correlated with polymorphisms of selected genes involved in different mechanisms of DNA repair such as : XRCC1 [ base excision repair ] ; XPA, XPC, XPG, XPD, XPF, ERCC1 [ nucleotide excision repair ], NBS1, RAD51, XRCC2, XRCC3, RAD51, and BRCA1 [ homologous recombination ], as well as in genes encoding xenobiotic metabolizing enzymes, such as CYP1A, CYP2E1, NAT2, GSTT1, and EPHX ( mEH ) ... Our study indicated that, of the polymorphisms studied, only XPC ( exon 15 and intron 11 ) is associated with BLM induced CAs , suggesting a role of the NER pathway in the repair of BLM induced chromosomal aberrations