Gene interactions and pathways from curated databases and text-mining

◀ Back to EPHB2

BMP2 — EPHB2

Text-mined interactions from Literome

Lou et al., Biochem Biophys Res Commun 2000 : Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2 ... These results indicate that Erk is involved in BMP-2 induced osteoblast differentiation
Gallea et al., Bone 2001 (MAP Kinase Signaling System) : This report shows that BMP-2 activates ERK and p38, but not JNK, in C2C12 cells
Xing et al., Biochem Biophys Res Commun 2002 : The role of Sp1 in BMP2-up regulated Erk2 gene expression ... In this study, the molecular mechanism which mediates the regulation of Erk2 gene expression by BMP2 was investigated ... Northern blot analysis showed that increased Erk2 protein level under BMP2 inducement comes from BMP2-up regulated Erk2 mRNA expression ... Transfection studies showed that the addition of the Sp1 binding inhibitor mithramycin or mutation of the Sp1 site residing at -147/-139 abolishes the up-regulation of Erk2 promoter activity induced by BMP2 ... All these results indicate that Sp1 mediated transcription is one of the mechanisms, which is responsible for BMP2 induced up-regulation of Erk2 expression
Seghatoleslami et al., J Cell Biochem 2003 : While high expression of aggrecan and type IIB collagen genes were dependent on BMP-2 signaling, ERK inhibition of BMP-2 treated micromass cultures resulted in reduced activity of both genes
Kuo et al., J Pharmacol Exp Ther 2005 (MAP Kinase Signaling System...) : Pretreatment of osteoblast cells with noggin abrogated p38 activation but only partially decreased ERK1/2 activation, suggesting that BMP-2 signaling is required in p38 activation and is partially involved in ERK1/2 activation in osthole treated osteoblast cells
Izumi et al., J Mol Cell Cardiol 2006 : The role of extracellular signal regulated kinase ( ERK ) 1/2 cascade activated by LIF was highlighted by the use of a MAPK/ERK kinase (MEK) 1/2 inhibitor, U0126, or overexpression of dominant negative form of MEK1 that abolished sustained phosphorylation of Smad1 and cell survival effect induced by co-stimulation of LIF with BMP2, while BMP2 alone did not activate ERK1/2
Fan et al., J Cell Physiol 2006 (Cholestasis, Extrahepatic...) : Furthermore, BMP4 stimulated phosphorylation of Smad1 and ERK1/2 in HSCs
Maeda et al., J Biochem 2009 : Interestingly, CCN2-BMP-2 did not affect the BMP-2/CCN2 induced phosphorylation of p38 MAPK but caused less phosphorylation of ERK1/2 in cultured chondrocytes
Ghayor et al., Biochem Biophys Res Commun 2009 : On the other hand, BMP2 induced Erk phosphorylation ( p44/p42 ) and cell proliferation were suppressed in the presence of cAMP
Otani et al., J Endocrinol 2009 : BMP2 and BMP4 also suppressed estrogen induced phosphorylation of ERK1/ERK2 and SAPK/JNK signaling, suggesting that BMP2 and BMP4 downregulate estrogen effects by attenuating ER-MAPK signaling
Jun et al., J Biol Chem 2010 : Because BMP signaling induces Erk activation in osteoblasts, we sought to investigate whether BMP induced Erk signaling regulates Runx2 acetylation and stability
Su et al., J Biol Chem 2011 : Inhibition of NF-?B and ERK1/2 reduced BMP-2 expression whereas inhibition of p38 MAPK had no effect
Takeda et al., Mol Cell Endocrinol 2012 (MAP Kinase Signaling System) : Thus, the difference between BMP-6 and BMP-7 in enhancing GnRH induced FSHß transcription may be due to the differential effects of BMP ligands on GnRH induced ERK signaling
Ge et al., J Bone Miner Res 2012 (MAP Kinase Signaling System) : Significantly, in the presence of AA, BMP2/7 synergistically stimulated RUNX2 S319 phosphorylation and transcriptional activity without affecting total RUNX2 and this response was totally dependent on ERK/MAPK activity ... Significantly, in the presence of AA, BMP2/7 synergistically stimulated RUNX2 S319 phosphorylation and transcriptional activity without affecting total RUNX2 and this response was totally dependent on ERK/MAPK activity ... Based on this work, we conclude that extracellular matrix and BMP regulation of RUNX2 phosphorylation and transcriptional activity in osteoblasts is predominantly mediated by ERK rather than p38 MAPKs
Li et al., Cell stem cell 2012 : Here, we show that, whereas LIF sustains relatively high ERK activity, BMP4 can steadily attenuate ERK activity by upregulating ERK-specific dual-specificity phosphatase 9 (DUSP9)
Li et al., Protein Cell 2012 : We recently found that while LIF signaling augments ERK activity, BMP signaling inhibits ERK activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9
Park et al., Anticancer Drugs 2013 (Bone Neoplasms...) : Whereas BMP-2 mainly activated ERK1/2 , BMP-9 phosphorylated p38 within 1 h. pBMP-2 did not activate either the Smad or ERK/p38, whereas pBMP-9, like BMP-9, induced both Smad1/5/8 and p38 phosphorylation
Zeng et al., Arterioscler Thromb Vasc Biol 2013 (Aortic Valve Stenosis...) : Inhibition of ERK1/2 or nuclear factor-?B also reduced bone morphogenetic protein-2 and alkaline phosphatase expression induced by lipopolysaccharide