Gene interactions and pathways from curated databases and text-mining

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BRAF — PARP1

Text-mined interactions from Literome

Okada et al., Mol Cell Biol 1999 : B-Raf carrying this mutation was not activated by Rap1A but retained its response to Ras
Carey et al., J Biol Chem 2003 : In contrast to Raf-1, B-Raf is activated by Rap1
Dillon et al., J Biol Chem 2003 : Recent studies suggest that Rap1 can activate the MAP kinase kinase kinase B-Raf that is either endogenously or ectopically expressed
Calipel et al., J Biol Chem 2006 (Cell Transformation, Neoplastic...) : This ruled out a role for Rap1 in the PKA mediated B-Raf/ERK activation in ( WT ) B-Raf cells
Wang et al., Mol Cell Biol 2006 : Rap1 activation by Epac-CAAX, but not wild-type Epac, triggers its association with B-Raf
Ohtsuka et al., J Biol Chem 1996 : Here we have used this assay system and examined the effect of Rap1 on the B-Raf activity to phosphorylate recombinant MAP kinase kinase ( MEK ) ... Recombinant Rap1B stimulated the activity of B-Raf , which was partially purified from bovine brain and immunoprecipitated by an anti-B-Raf antibody ... Rap1B enhanced the Ki-Ras stimulated B-Raf activity in an additive manner
Kuroda et al., J Biol Chem 1996 : Different effects of various phospholipids on Ki-Ras-, Ha-Ras-, and Rap1B induced B-Raf activation ... Moreover, we found that Rap1B as well as Ki-Ras and Ha-Ras stimulate the B-Raf activity ... Since B-Raf contains a cysteine-rich domain originally found in protein kinase C as a domain responsible for interaction with phosphatidylserine ( PS ) and diacylglycerol or 12-O-tetradecanoylphorbol-13-acetate, we have examined here the effect of these compounds on the Ki-Ras-, Ha-Ras-, and Rap1B induced activation of bovine brain B-Raf ... However, none of the above phospholipids affected the Ha-Ras stimulated B-Raf activity, whereas PI, PS, phosphatidylethanolamine, and phosphatidic acid inhibited the Rap1B stimulated B-Raf activity ... Phosphatidylcholine or PI-4-monophosphate did not show any effect on the Rap1B stimulated B-Raf activity ... Synthetic PS with two unsaturated fatty acids, such as 1,2-dioleoyl-PS or 1,2-dilinoleoyl-PS, showed the same effect toward the Ki-Ras- and Rap1B stimulated B-Raf activities, but synthetic PS with two saturated fatty acids, such as 1, 2-distearoyl-PS, was inactive ... 12-O-Tetradecanoylphorbol-13-acetate did not affect the stimulatory or inhibitory effect of PS on the Ki-Ras- and Rap1B stimulated B-Raf activities, respectively ... These results indicate that various phospholipids differently affect Ki-Ras-, Ha-Ras, and Rap1B induced B-Raf activation
Vossler et al., Cell 1997 : These cell type-specific actions of cAMP require the expression of the serine/threonine kinase B-Raf and activation of the small G protein Rap1 ... Rap1 , activated by mutation or by the cAMP dependent protein kinase PKA, is a selective activator of B-Raf and an inhibitor of Raf-1