Brignone et al., J Immunol 2007
:
Early APC activation by IMP321 is needed for this Tc1-type activation because pure sorted CD8+ T cells could not be activated by IMP321
Brignone et al., Journal of translational medicine 2010
(Breast Neoplasms...) :
IMP321 induced both a sustained increase in the number and activation of APC ( monocytes and dendritic cells ) and an increase in the percentage of NK and long lived cytotoxic effector-memory CD8 T cells