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BRCA1 — CDK4

Pathways - manually collected, often from reviews:

• Reactome Reaction: BRCA1 → CDK4 (direct_complex) Masson et al., EMBO J 1999, Sehorn et al., Nature 2004, Oliver-Bonet et al., Mol Hum Reprod 2005, Thorslund et al., EMBO J 2007, Oliver-Bonet et al., Mol Hum Reprod 2007, Sheridan et al., Nucleic Acids Res 2008, Okorokov et al., PloS one 2010, Scully et al., Cell 1997, Barlow et al., EMBO J 1997, Golub et al., Nucleic Acids Res 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: BRCA1 — CDK4 Wang et al., Oncogene 1997
• IRef Bind_translation Interaction: BRCA1 — CDK4 (affinity chromatography technology) Wang et al., Oncogene 1997
• IRef Biogrid Interaction: BRCA1 — CDK4 (direct interaction, enzymatic study) Miralem et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: BRCA1 — CDK4 (direct interaction, pull down) Wang et al., Oncogene 1997
• IRef Biogrid Interaction: BRCA1 — CDK4 (direct interaction, enzymatic study) Kehn et al., Oncogene 2007*
• IRef Hprd Interaction: BRCA1 — CDK4 (in vivo) Wang et al., Oncogene 1997
• IRef Hprd Interaction: BRCA1 — CDK4 (in vitro) Wang et al., Oncogene 1997
• IRef Ophid Interaction: BRCA1 — CDK4 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wang et al., J Biol Chem 2000 (Breast Neoplasms...) : Moreover, ectopic expression of cyclin D1 and Cdk4 can stimulate the Brca1 promoter in an E2F dependent manner, and this is inhibited by coexpression of the p16(INK4a) cyclin dependent kinase inhibitor
Ouchi et al., Proc Natl Acad Sci U S A 2000 : After IFN-gamma treatment, induction of the cyclin dependent kinase inhibitor, p21WAF1, was synergistically activated by BRCA1 , whereas the IRF-1 gene was unaffected