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CA1 — PAF1

Text-mined interactions from Literome

Yue et al., J Pharmacol Exp Ther 1991 : PAF induced an immediate and concentration dependent increase in [ Ca++]i with an EC50 of 6.8 nM ... The calcium channel blockers nifedipine ( 5 microM ) and diltiazem ( 10 microM ) had no effect on the PAF induced increase in [ Ca++]i , but omission of CA++ from the incubation buffer caused an 82 % reduction of PAF induced [ Ca++]i elevation ; the remainder contributed from intracellular sources was completely inhibited by 10 microM TMB-8, an intracellular Ca++ blocker
Shamsuddin et al., Am J Respir Cell Mol Biol 1995 : CaI stimulation increased PAF synthesis 3-fold ( P < 0.001 ), LTB4 synthesis 20-fold ( P < 0.001 ), and PLA2 activity 52 % ( P < 0.001 ) ... The same dose of PAF ( 2.5 microM ) decreased CaI stimulated PAF synthesis 40 % ( P < 0.02 )
Bkaily et al., Br J Pharmacol 1993 (Ion Channel Gating) : The PAF induced effect on [ Ca]i was blocked by the PAF receptor antagonist, WEB2170
Katnik et al., J Membr Biol 1993 : When exogenously applied to human monocyte derived macrophages ( HMDMs ), PAF induces a rapid rise in cytosolic free calcium (Cai) believed to be an early triggering event in macrophage activation