Gene interactions and pathways from curated databases and text-mining

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BDNF — CA2

Text-mined interactions from Literome

Tabuchi et al., J Biol Chem 2000 (Calcium Signaling) : Differential activation of brain derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage dependent and N-methyl-D-aspartate receptor Ca2+ channels
Mizoguchi et al., Eur J Neurosci 2002 (Calcium Signaling...) : Brain derived neurotrophic factor (BDNF) increases postsynaptic intracellular Ca2+ and modulates synaptic transmission in various types of neurons
Kingsbury et al., J Biol Chem 2003 : The coordinated regulation of BDNF and trkB by Ca2+ may play a role in activity dependent survival and synaptic plasticity by enhancing BDNF signaling in electrically active neurons
Mizoguchi et al., Neuroreport 2003 : BDNF increased intracellular Ca2+ through the PLC-gamma phosphorylation after the TrkB receptor tyrosine kinase activation
Poulsen et al., Neuroscience 2004 (Seizures) : Activity dependent brain derived neurotrophic factor (BDNF) expression is Ca2+ dependent , yet little is known about the Ca2+ channel contributions that might direct selective expression of the multiple BDNF transcripts
Li et al., Nature 2005 (Calcium Signaling) : The BDNF induced chemo-attraction of axonal growth cones requires Ca2+ signalling, but how Ca2+ is regulated by BDNF at the growth cone remains largely unclear
Yagasaki et al., J Biol Chem 2006 : We found that the BDNF stimulated PLC-gamma activation and the ensued increase in intracellular Ca2+ ( [ Ca2+ ] i ) were potentiated by pretreatment with imipramine or fluvoxamine, so was the BDNF induced glutamate release
Jia et al., Nat Neurosci 2007 : In CGN cultures, blocking TRPC channels or downregulating TRPC3 or 6 suppressed brain derived neurotrophic factor (BDNF) mediated protection, BDNF triggered intracellular Ca2+ elevation and BDNF induced CREB activation
Zheng et al., J Neurochem 2008 (Ion Channel Gating) : Interestingly, sub-nanomolar BDNF did not stimulate [ Ca2+ ] i increase under our culture conditions
McGurk et al., J Neurosci 2011 (Synaptic Transmission) : Functionally, XTRPC1 was required specifically in postsynaptic myocytes for BDNF induced Ca2+ elevation and full synaptic potentiation at the NMJ, suggesting a previously underappreciated postsynaptic function of Ca2+ signaling in neurotrophin induced synaptic plasticity, in addition to its well established role at presynaptic sites
Marsh et al., J Neurochem 1996 : The effects of both NT-3 and BDNF on Ca2+ levels were attenuated in Ca ( 2+ ) -free medium, suggesting that both neurotrophins increase Ca2+ flux across the plasma membrane as well as release from internal stores
Tao et al., Neuron 1998 : This report describes experiments demonstrating that CREB or a closely related protein mediates Ca2+ dependent regulation of BDNF , a neurotrophin that modulates synaptic activity