Gene interactions and pathways from curated databases and text-mining

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CASP10 — SMAD4

Text-mined interactions from Literome

Xu et al., Mol Cancer Res 2006 (Carcinoma...) : Silencing of Bax by small interfering RNA in IOSE397 cells significantly reduced ALK7-ca induced apoptosis as measured by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling assay but partially blocked ALK7-ca induced caspase-3 activation and did not affect the down-regulation of Xiap by ALK7-ca. Dominant negative Smad2, Smad3, and Smad4 blocked ALK7-ca regulated Xiap and Bax expression and caspase-3 activation
Huang et al., Oncol Rep 2008 (Carcinoma, Hepatocellular...) : Western blot analysis revealed that p16 was up-regulated and caspase 3 was activated by silencing of Smad4 , and the expression of p21 and wild-type p53 were not affected