Gene interactions and pathways from curated databases and text-mining

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CASP3 — KDR

Text-mined interactions from Literome

Yilmaz et al., Biochem Biophys Res Commun 2003 : These data indicate that activation of VEGFR-2 prevents endothelial cell apoptosis by inhibiting p38 MAPK phosphorylation and thus, reducing caspase-3 activity
You et al., Am J Pathol 2010 (Neovascularization, Pathologic) : Loss of VEGFR-2 was followed by increased activated caspase-3 in tumor vessels
Abdul Muneer et al., Arterioscler Thromb Vasc Biol 2012 (Disease Models, Animal...) : Alcohol induced MMPs activation is a key mechanism for dysfunction of BBB via degradation of VEGFR-2 protein and activation of caspase-1 or IL-1ß release
Zheng et al., Kaohsiung J Med Sci 2013 (Carcinoma, Adenoid Cystic...) : These effects may be related to the downregulation of VEGFR-2 expression and the activation of caspase-3 expression