Gene interactions and pathways from curated databases and text-mining

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CASP6 — IGF1

Text-mined interactions from Literome

Leverrier et al., Cell Death Differ 1999 : Moreover, PI3-kinase activity is also necessary for inhibition of apoptosis and caspase regulation by IGF-1 but not IL-3
Takadera et al., J Neurochem 1999 : Insulin-like growth factor I completely attenuated MK-801 induced apoptotic cell death and caspase-3 activation
Russell et al., Neurobiol Dis 1999 (Diabetes Mellitus, Experimental...) : In contrast, addition of IGF-I , even at physiological concentrations, prevents activation of caspase-3 and neuronal apoptosis in vitro
Matsuzaki et al., J Neurochem 1999 : Incubation of neurons with a P13-kinase inhibitor, wortmannin or LY294002, blocked the effects of IGF-1 on NO-induced neurotoxicity and caspase-3-like activation
Cheng et al., J Neurochem 2001 : Insulin-like growth factor-I , via phosphatidylinositol-3 kinase, inhibits caspase activation and rescues Schwann cells from serum withdrawal induced apoptosis
Kondo et al., Cell Death Differ 2002 : Moreover, IGF-1 inhibited C2-ceramide induced decrease of mitochondrial membrane potential, and increase of cytochrome c release, caspase-3 cleavage and caspase-3 activity as judged by PhiPhiLux cleaving method ... Moreover, IGF-1 inhibited C2-ceramide induced decrease of mitochondrial membrane potential, and increase of cytochrome c release, caspase-3 cleavage and caspase-3 activity as judged by PhiPhiLux cleaving method
Linseman et al., J Neurosci 2002 : IGF-I blocked activation of the executioner caspase-3 and the intrinsic initiator caspase-9 in primary cerebellar granule neurons deprived of serum and depolarizing potassium
Burgess et al., J Neuroimmunol 2003 : These data establish that IGF-I inhibits activation of caspase-3 and promotes promyeloid cell survival through a PI 3-kinase dependent pathway, whereas IL-3 does not
Lo et al., J Orthop Res 2004 : Collagenase was added to the cells in the presence and absence of caspase inhibitors and insulin like growth factor (IGF)-1
Ness et al., Glia 2004 : IGF-I prevented glutamate induced loss of mitochondrial membrane potential, cytochrome c release, and caspase-9 activation ... Moreover, IGF-I prevented caspase-3 activation in pro-OLs as long as 8 h after exposure of the cells to glutamate, suggesting that delayed activation of IGF-I mediated survival pathways can block glutamate mediated apoptosis in pro-OLs ... Moreover, IGF-I prevented caspase-3 activation in pro-OLs as long as 8 h after exposure of the cells to glutamate, suggesting that delayed activation of IGF-I mediated survival pathways can block glutamate mediated apoptosis in pro-OLs
Leinninger et al., Cell Death Differ 2004 (Neuroblastoma) : IGF-I prevents caspase activation and mitochondrial events leading to apoptosis ... These results suggest that elevated glucose produces early initiator caspase activation, followed by Delta Psi ( M ) changes, in neuroblastoma cells ; in turn, IGF-I prevents apoptosis by preventing downstream caspase activation, maintaining Delta Psi ( M ) and regulating Bcl proteins ... These results suggest that elevated glucose produces early initiator caspase activation, followed by Delta Psi ( M ) changes, in neuroblastoma cells ; in turn, IGF-I prevents apoptosis by preventing downstream caspase activation, maintaining Delta Psi ( M ) and regulating Bcl proteins
Kuemmerle et al., Am J Physiol Gastrointest Liver Physiol 2005 : Endogenous IGF-I inhibited beta-catenin phosphorylation, caspase 3 activation, and apoptosis induced by serum deprivation
Zhou et al., Zhong Xi Yi Jie He Xue Bao 2005 : Immunohistochemical and integral optical density analytic methods were used to observe the effects of Yiqi Huayu Recipe-, Yiqi Recipe-, Huayu Recipe medicated sera and insulin-like growth factor 1 (IGF-1) on the expressions of bcl-2, Bax and caspase-8 of apoptotic anulus fibrosus cells in rats induced by anti-Fas antibody
Kwon et al., Life Sci 2006 (Stomach Neoplasms) : Thus, porphyran appears to negatively regulate IGF-IR phosphorylation by causing a decrease in the expression levels in AGS gastric cancer cells, and then inducing caspase-3 activation
Schlueter et al., Cell Death Differ 2007 : At the cellular level, IGF1R inhibition increased caspase 3 activity and induced neuronal apoptosis
Meyer et al., J Cell Biochem 2007 (Neuroblastoma) : NDGA inhibits growth of neuroblastoma cells and induces apoptosis at higher doses, causing IGF-I-resistant activation of caspase-3 and a large increase in the fraction of sub-G0 cells
Himpe et al., J Endocrinol 2008 : IGF1 did not affect Fas expression or activation by anti-Fas of caspase-8 , but inhibited the depolarization of the mitochondrial membrane
Yang et al., BMC cancer 2009 (Colorectal Neoplasms) : Using three colorectal cancer cell lines and one muscle cell line, associations between IGF-I and activities of caspase 3/7, 8 and 9 have been examined ; the role of insulin-like growth factor I receptor ( IGF-IR ) in the caspase activation has been investigated ... The results show that exogenous IGF-I significantly increases activity of caspases 3/7, 8 and 9 in all cell lines used ; blocking IGF-I receptor reduce IGF-I induced caspase activation ... Further studies demonstrate that IGF-I induced caspase activation does not result in cell death
Shushanov et al., Bull Exp Biol Med 2010 : Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1ß in the rat eye retinal neurons ... Insulin and insulin-like growth factor-1 and their combination inhibit caspase-3/7 activation in these cells, induced by removal of the serum from culture medium and/or by IL-1ß treatment
Lai et al., Hum Gene Ther 2012 (Fibrosis...) : Activation of IGF-I expression reduced cardiac fibrosis ( p=0.048 ), apoptosis ( p < 0.0001 ), and caspase-3/7 activity ( p=0.04 )
Wang et al., Endocrinology 1998 : To investigate IGF-I actions on apoptosis of H9C2 cardiac muscle cells, we have defined the effects of IGF-I on Bcl-2, Bax, caspase 3, DNA fragmentation, and cell survival ... IGF-I partially inhibited Bax induction, caspase 3 activation, DNA fragmentation, and enhanced cell survival
Russell et al., J Neurobiol 1998 : We further studied the role of IGF-I signaling and caspase inhibition after NGF withdrawal ... Both IGF-I and Boc-aspartyl ( OMe ) -fluoromethylketone ( BAF ), a caspase inhibitor , equally reduced apoptosis after NGF withdrawal
Suzuki et al., FEBS Lett 1998 : It was also found that R-Ras and IGF-1 cooperatively induced Bcl-xL expression and inhibited caspase-3 activation