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CASP6 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CASP6 → TNF (increases) Nyormoi et al., Mol Cell Biol 2001*
  Evidence: Treatment of cells with antagonists of Caspase 6 inhibited both the TNF alpha induced downregulation of AP2 alpha expression and TNF alpha induced cell death.
• NCI Pathway Database Caspase Cascade in Apoptosis: TNF-alpha (TNF) → Caspase 6 (CASP6) (modification, activates) Nyormoi et al., Mol Cell Biol 2001*

Text-mined interactions from Literome

Manna et al., Biochem Pharmacol 1999 : TNF induced cytotoxicity and activation of caspase-3 were also abolished by beta-lapachone
Rojas et al., J Immunol 1999 : Anti-TNF-alpha inhibited apoptosis, diminished NO- production, p53, and caspase 1 activation and increased Bcl-2 expression
Niwa et al., Eur J Pharmacol 1999 : DbcAMP also inhibited the TNF-alpha/cycloheximide induced activation of caspase-3 , but it had no effect on the activation of caspase-8 in human neutrophils
Wright et al., J Biol Chem 1999 : In addition, IFN-gamma/TNF-alpha and IL-1alpha/IFN-gamma/TNF-alpha stimulate activation of caspase-8 and caspase-3, which IL-13 pretreatment was able to partially inhibit and delay
Ruemmele et al., Biochem Biophys Res Commun 1999 (Necrosis) : Western blot analyses confirmed that caspase-3 was not activated in response to TNFalpha
Faraco et al., Biochem Biophys Res Commun 1999 : TNF induces caspase activity in both settings, and the broad spectrum caspase inhibitor zVAD-fmk inhibits this activity and blocks both TNF induced apoptosis and necrosis
Meerarani et al., Am J Clin Nutr 2000 : Our results indicated that linoleic acid and TNF-alpha independently, but more markedly in concert, up-regulated caspase-3 activity and induced annexin V binding and DNA fragmentation
Hirahashi et al., Kidney Int 2000 : Overexpression of I kappa B delta N augmented TNF-alpha induced caspase-3 and caspase-8 activity, but did not affect Bcl-2 or Bax protein expression
Bai et al., J Biol Chem 2000 : Addition of H ( 2 ) O ( 2 ) prevented TNF-alpha induced apoptosis and caspase activation, an effect prevented by simultaneous addition of catalase
De Nadai et al., Proc Natl Acad Sci U S A 2000 (Second Messenger Systems) : In combination with TNF-alpha, however, ceramide potentiated, whereas NO inhibited, TNF-alpha induced TRADD recruitment and caspase 8 activity
Manna et al., J Immunol 2000 : TNF induced cytotoxicity, caspase activation, and lipid peroxidation were also abolished by vesnarinone
Manna et al., J Immunol 2000 : Resveratrol also inhibited the TNF induced activation of mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation
Tafani et al., Am J Pathol 2000 : Cytochrome c-dependent activation of caspase-3 by tumor necrosis factor requires induction of the mitochondrial permeability transition
Deshpande et al., FASEB J 2000 : Expression of Rac1N17 blocked TNF induced activation of nuclear factor-kappa B (NF-kappaB), increased activity of caspase-3 , and markedly augmented endothelial cell susceptibility to TNF induced apoptosis
Nakamura et al., Lab Invest 2000 (Sjogren's Syndrome) : However, XIAP expression was down-regulated by TNF-alpha , which induced apoptotic cell death of HSG cells with an increase in caspase-3 activity
Rodenburg et al., Arthritis Rheum 2000 : Interestingly, the reduced expression of LPS induced TNFalpha in the presence of SSZ was restored by inhibition of caspase 8 ... Inhibition of TNFalpha expression in macrophages by SSZ is due to the induction of apoptosis and involves the activation of caspase 8
Obara et al., Arterioscler Thromb Vasc Biol 2000 (Arteriosclerosis) : The induction was suppressed by treatment with a selective inhibitor of the caspase-3 family, Z-DEVD-fmk, and the overexpression of IkappaBDeltaN induced TNF-alpha mediated caspase-3 and caspase-2 activity
Guicciardi et al., J Clin Invest 2000 : Consistent with these observations, the ability of TNF-alpha/AcD to induce mitochondrial release of cytochrome c, caspase activation, and apoptosis of isolated hepatocytes was markedly diminished in cells from CatB ( -/- ) mice
Tudan et al., J Immunol 2000 (MAP Kinase Signaling System) : Furthermore, the inhibition of the Mek1/Mek2 -- > ERK1/ERK2 or PI3-K/Akt pathways reversed CPPD crystal associated suppression of TNF-alpha induced caspase 3 activation and neutrophil apoptosis
Messmer et al., J Am Soc Nephrol 2000 : In mechanistic terms, bFGF synergistically increased TNF-alpha induced mitochondrial permeability transition, the release of cytochrome c from mitochondria to the cytosol, and upregulation of the proapoptotic protein Bak and significantly enhanced activation of caspase-8 protease activity ... In contrast, stress activated protein kinase and nuclear factor kappaB activation, which represent primary signals of TNF/TNF receptor interaction, downregulation of the antiapoptotic protein Bcl-x ( L ), and caspase-3-like protease activation , were unaffected
Qin et al., J Biol Chem 2001 : CsA blocked the TNF-alpha induced release of pro-caspase 8 but not cytochrome c. Internucleosomal DNA fragmentation started at 6 h and peaked 12 h after TNF-alpha treatment
Pelagi et al., Eur Cytokine Netw 2000 (Necrosis) : TNF induced caspase activation is critically involved in both apoptosis and protection from cell necrosis
Shrivastava et al., Antioxid Redox Signal 1999 : TNF induced activation of caspase activity was blocked by all three types of quenchers
Nakagami et al., Hypertension 2001 : On the other hand, treatment with rHGF attenuated the increase in LDH release and caspase-3 activity induced by tumor necrosis factor-alpha stimulation
Zhao et al., J Neurosci Res 2001 : TNF-alpha stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures ... Results of this study suggest TNF-alpha may induce caspase-3 activation but not calpain activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis
You et al., J Biol Chem 2001 : Intriguingly, unlike the caspase-8 inhibitor cellular FADD-like interleukin-1 beta converting enzyme-inhibitory protein ( c-FLIP ), NDED suppressed TNF mediated apoptosis by inhibiting TNF induced caspase-8 enzymatic activity but not the processing of caspase-8
Petrache et al., Am J Physiol Lung Cell Mol Physiol 2001 (Respiratory Distress Syndrome, Adult) : Reductions in MLC phosphorylation by the inhibition of either MLC kinase ( ML-7, cholera toxin ) or Rho kinase ( Y-27632 ) dramatically attenuated TNF-alpha induced stress fiber formation, indexes of apoptosis, and caspase-8 activity but not TNF-alpha induced barrier dysfunction
Liu et al., Oncogene 2001 : A TNFR1-antagonistic mAb or a TRAIL decoy receptor inhibited the activation of caspase-8 and the subsequent apoptosis induced by TNFalpha or TRAIL, respectively, in the cells
Perlman et al., Eur J Immunol 2001 : Here, we demonstrate that LPS and TNF-alpha up-regulate Flip and suppress spontaneous Fas-FasL mediated monocyte apoptosis and caspase 8 and 3 activation
Brown et al., Alcohol Clin Exp Res 2001 : Furthermore, there was a progressive increase in the sensitivity of the cells to H2O2 or TNF-alpha induced cytochrome c release, caspase 3 activation, apoptosis, and necrosis ( p < or = 0.05 )
Al-Zoubi et al., J Biol Chem 2001 : Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha induced apoptosis and activation of caspase-8 and -3 ... However, relative to control cells, only cells expressing IG20 showed enhanced TNF-alpha induced activation of caspase-8 and -3, whereas cells expressing DENN-SV showed either reduced or no caspase activation ... Our results show that IG20 can promote TNF-alpha induced apoptosis and activation of caspase-8 and -3 and suggest that it may play a novel role in the regulation of the pleiotropic effects of TNF-alpha through alternative splicing
Hoffmann et al., Circ Res 2001 : In aged cells, oxLDL and tumor necrosis factor-alpha induced apoptosis and caspase-3-like activity were significantly enhanced more than 3-fold compared with young cells ( passage 3 )
Mukhopadhyay et al., J Cell Biochem 2002 : Additionally, TNF induced caspase-3 and caspase-8 activation and TNF induced PARP cleavage were unaffected by the presence or absence of STAT1
Coletti et al., EMBO J 2002 (Cachexia) : TNFalpha mediated caspase activation and block of differentiation are dependent upon the expression of PW1, but occur independently of NFkappaB activation
Menon et al., J Assist Reprod Genet 2002 : TNF-alpha promotes caspase activation and apoptosis in human fetal membranes ... TNF increases proapoptotic p53 levels and caspase activities in fetal membranes
Fotin-Mleczek et al., J Cell Sci 2002 (Rhabdomyosarcoma) : Apoptotic crosstalk of TNF receptors : TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1 dependent activation of caspase-8
Chen et al., Int J Cancer 2002 (Glioma...) : Therefore, Kupffer cells execute their anti-tumor effect via increasing the production of NO, TNFalpha and IFNgamma and these cytotoxic molecules inhibit the growth of tumor by damaging cellular DNA and inducing apoptosis that was featured by downregulation of Bcl-2 but upregulation of caspase-8
Mattana et al., Infect Immun 2002 : We demonstrate here that ADP constitutively released in the medium by A. castellanii, interacting with specific P2y(2) purinoceptors expressed on the monocytic cell membrane, caused a biphasic rise in [ Ca ( 2+ ) ] ( i ), morphological changes characteristics of cells undergoing apoptosis, caspase-3 activation , and secretion of tumor necrosis factor alpha (TNF-alpha)
Mackus et al., Int Immunol 2002 : CD40 ligation and TNF-alpha prevented release of cytochrome c and activation of caspase-3 , which could not be explained by effects on the expression of Bcl-2, Bcl-x ( L ) or Bax
Goswami et al., Neurochem Res 2002 : TNF-alpha activated caspase 8 and caspase 3 in PC12 cells, leading to cell death by apoptosis ( DNA fragmentation )
Langelier et al., J Gen Virol 2002 : Activation of caspase-8 induced either by TNF or by Fas ligand expression was prevented by the R1 protein
Chua et al., Biochim Biophys Acta 2002 : Our results demonstrate that TGF-beta1 can decrease TNF-alpha induced apoptosis in murine osteoblasts at least in part by attenuating TNF-alpha induced caspase gene expression
Pavalko et al., J Cell Physiol 2003 : FSS activated PI3-kinase signaling, induced phosphorylation of Akt, and inhibited TNF-alpha induced activation of caspase-3
Ashton et al., J Biol Chem 2003 : TNFalpha mediated TNFR1-FADD association and caspase 8 activation were not inhibited by IBOP co-stimulation, however, resulting in a 2.6-fold increase in endothelial cell apoptosis
Perez et al., J Virol 2003 : E1A promoted TNF-alpha mediated activation of caspase-8 , suggesting that sensitivity was occurring at the level of the death inducing signaling complex
Irawaty et al., Autoimmunity 2002 : TNF + IFNgamma did not induce caspase 3 activation in primary mouse islets
Weitsman et al., Int J Cancer 2003 (Breast Neoplasms) : The antioxidants N-acetylcysteine, reduced glutathione, lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on TNFalpha induced caspase activation ... The effect of calcitriol on DeltaPsi was mimicked by rotenone, which increased both the drop in DeltaPsi and caspase activation induced by TNFalpha
Nyormoi et al., Apoptosis 2003 : Here we show that zDRHDfmk inhibits TNFalpha induced caspase 6 activity and apoptosis in breast cancer cells
Weishaupt et al., Neurobiol Dis 2003 : Although caspase-8 is known to be involved in death-receptor dependent apoptosis, measurable caspase-8 activity or even RGC death could be induced by neither tumor necrosis factor-alpha nor Fas ligand injections into unlesioned eyes
Epperly et al., Exp Hematol 2003 : The cell lines overexpressing MnSOD ( 1F2 or 2C6 ) displayed decreased radiation induced, TNF-alpha induced, or IL-3 withdrawal induced mitochondrial membrane permeability, caspase-3 and PARP activation, and apoptosis
Bhattacharya et al., Am J Physiol Gastrointest Liver Physiol 2003 : SP-600125, a specific inhibitor of JNK activation, prevented cytochrome c release from mitochondria, JNK activation, DNA fragmentation, and caspase-9 activation in response to TNF-alpha/CHX
Ramos et al., Mol Pharmacol 2003 (Necrosis...) : Both C2-ceramide and TNFalpha + CHX increased caspase 8- and 3-like activities in cytosolic extracts ; however, treatment of cells with the broad-spectrum caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone protected NB16 cells from TNFalpha + CHX induced cell death but did not prevent C2-ceramide cytotoxicity
Lagunoff et al., Int Rev Immunol 2003 : Virally encoded genes inhibit the activation of caspase-8 by the TNF receptor and Fas ; activate NF-kappaB to increase expression of antiapoptotic genes ; inhibit interferon response ; bind to p53, thereby blocking p53 dependent apoptosis ; and interact with other pro- and antiapoptotic cellular genes
Wang et al., Zhonghua Nei Ke Za Zhi 2003 (Disease Models, Animal...) : Hepatocyte apoptosis and liver injury and the expression of caspase-3 could be blocked by antagonizing TNFalpha
Deng et al., Cell 2003 : Tumor necrosis factor ( TNFalpha ) receptor signaling can simultaneously activate caspase 8, the transcription factor, NF-kappaB and the kinase, JNK
Bhattacharya et al., Am J Physiol Gastrointest Liver Physiol 2004 : Pretreatment of polyamine depleted IEC-6 cells with a cell membrane-permeable MEK1/2 inhibitor, U-0126, significantly inhibited TNF-alpha/CHX induced ERK phosphorylation and significantly increased DNA fragmentation, JNK activity, and caspase-3 activity in response to TNF-alpha/CHX
Kimura et al., Brain Res 2003 (Subarachnoid Hemorrhage) : TNF-alpha induces apoptosis in cultured cerebral endothelial cells through the cleavage of caspase-3
Liu et al., Mol Cell 2003 : In the October 3 issue of Cell, Deng et al. ( 2003 ) report that a JNK dependent mitochondrial signal, the release of Smac/DIABLO, is required for TNF induced caspase 8 activation and apoptosis
Dong et al., Apoptosis 1998 : This dominant mutation in II-5 cells blocks TNF alpha induced disruption of mitochondrial membrane potential and caspase-3 activation
Giri et al., Apoptosis 1999 : When examined for apoptosis, vincristine resistance suppressed the cytotoxic effects and caspase-3 activation by TNF ... Thus, overall these results indicate that vincristine resistance correlates with suppression of NF-kappa B activation, cytotoxicity, and caspase-3 activation but enhancement of JNK activation by TNF
Lambert et al., Int J Cancer 2004 (Sarcoma, Experimental) : In addition, 2-methoxyestradiol treatment caused upregulation of death receptor ligands FasL and TNFalpha and induced caspase-8 activation
Papakonstanti et al., Mol Biol Cell 2004 : Additionally, the actin filament stabilizer phallacidin potently blocked the nuclear translocation of nuclear factor-kappaB and its binding activity, resulting in abrogation of the TNF-alpha induced inhibition of caspase-3
Jones et al., Exp Cell Res 2004 (Colorectal Neoplasms) : The effect of specific caspase inhibitors on TNF-alpha and butyrate induced apoptosis of intestinal epithelial cells
Schwabe et al., FASEB J 2004 : In primary rat hepatocytes expressing an IkappaB superrepressor, the JNK inhibitor SP600125 strongly decreased TNF-alpha induced cell death, caspase 3 activation, and DNA laddering
Weitsman et al., Ann N Y Acad Sci 2003 (Breast Neoplasms) : The antioxidants N-acetylcysteine, glutathione, lipoic acid, and ascorbic acid markedly reduced the effect of the hormone on TNF induced caspase activation, attesting to the involvement of reactive oxygen species ( ROS ) in the cross-talk between the hormone and the cytokine
Kim et al., Toxicol Appl Pharmacol 2004 (Necrosis) : P38 mediated caspase activation regulates mercury induced apoptosis and p38 mediated TNFalpha regulates necrosis in these cells
Chen et al., J Cardiovasc Pharmacol Ther 2004 : Pretreatment of cells with the PPAR-gamma ligand pioglitazone blocked TNF-alpha mediated apoptosis, caspase-3 activation, expression of Bcl-2, and lipid peroxidation ( P < .01 vs TNF-alpha alone )
Kimura et al., Int Immunol 2004 : Furthermore, in Jak-deficient cell lines, DNA fragmentation and caspase-8 activation by TNF-alpha are suppressed, indicating that Jaks participate in TNF-alpha induced apoptosis signaling
Chandra et al., Mol Cell Biol 2004 : Functional analyses with dominant negative mutants, small interfering RNAs, peptide inhibitors, and Fas associated death domain (FADD)- and caspase 8-deficient Jurkat T cells establish that the mitochondrion localized active caspase 8 results mainly from the FADD dependent and tumor necrosis factor receptor associated death domain dependent mechanisms and that caspase 8 activation plays a causal role in VP16 induced caspase 3 activation and cell death
Wang et al., Am J Physiol Cell Physiol 2004 : Both BzATP and TNF-alpha activated caspase-3 , suggesting that BzATP activates predominantly the mitochondrial apoptotic pathway
Yan et al., Immunol Cell Biol 2004 : In the presence of TNF-alpha or endotoxin ( LPS ), blockade of CD18 ( beta2 chain ) with mAb markedly increased caspase activation in PMN on fibrinogen
Zhao et al., J Toxicol Environ Health 2004 (Inflammation...) : The release of cytochrome c from mitochrondria, the activation of caspase-3 , -8, and -9, the cleavage of nuclear poly ( ADP-ribose ) polymerase ( PARP ), and the expression of TNF receptors ( TNF-R1/p55 and TNF-R2/p75 ), TNF-R associated factor 2 (TRAF2) , and cellular inhibitor of apoptosis 1 ( c-IAP1 ) were determined by immunoblotting
Alikhani et al., J Cell Physiol 2004 : Fluorometric studies demonstrated that TNF-alpha in vivo predominantly increased caspase-8 and -3 activity and by use of specific inhibitors, the activation of caspase-3 was shown to be initiated by caspase-8 with only a minor contribution from caspase-9
Tardy et al., J Biol Chem 2004 (Mucolipidoses) : These mutant cells exhibited a defect in TNF induced caspase activation, Bid cleavage, and release of cytochrome c
Gopee et al., Cell Biol Toxicol 2004 : The aim of current study was to investigate the effect of PKCalpha activation by FB1 on NF-kappaB activation and subsequently on TNFalpha gene expression and caspase 3 induction in LLC-PK1 cells
Misseri et al., American journal of physiology. Renal physiology 2005 (Inflammation...) : Renal obstruction induced increased tissue TNF-alpha and Fas ligand mRNA levels, TNF-alpha protein production, apoptotic renal tubular cell death, and elevated caspase 8 and 3 activity, whereas treatment with PEG-sTNFR1 significantly reduced obstruction induced TNF-alpha production, renal tubular cell apoptosis, and caspase activity
Wang et al., Mol Cell Biol 2004 : The pX-dependent expression of Fas/FasL and TNFR1/TNF-alpha mediates caspase 8 activation, resulting in Bid cleavage
Dong et al., Wound Repair Regen 2004 (Hyperglycemia) : After this treatment, cell proliferation, activation of mitogen activated protein kinase ( MAPK ), the level of apoptosis, and caspase-3 activation induced by removal of growth factors or tumor necrosis factor-alpha treatment were studied ... On the other hand, MCI-186 did not alter the level of apoptosis and caspase-3 activation induced by TNF-alpha treatment
McCabe et al., Toxicol Lett 2005 : The present work demonstrates that Hg2+ selectively disrupts death receptor mediated caspase-3 activation, where CD95 mediated caspase-3 activation is impaired in Hg2+ treated cells ; whereas TNF-alpha induced caspase-3 activation is not
Guthmann et al., Respir Res 2005 (Hyperoxia) : Inhibition of TNFalpha in vivo prevents hyperoxia mediated activation of caspase 3 in type II cells ... In the initiation phase of pulmonary oxygen toxicity, an increase of TNFalpha and its receptor TNFR1 leads to the activation of caspase 8 and 3 in TIIcells
Sun et al., Int J Cancer 2005 (Xeroderma Pigmentosum) : Moreover, overexpression of DDB2 in HR18 cells also attenuated TNF-alpha induced caspase activation
Rohrbach et al., J Mol Cell Cardiol 2005 : A similar DNA fragmentation and caspase 3 activation was induced by TNF-alpha , but without Bcl-xS/Bcl-xL increase, cytochrome c release or caspase 9 activation
Yang et al., Zhonghua Gan Zang Bing Za Zhi 2005 : [ Bcl-xl blocks tumor necrosis factor alpha induced caspase 8 activation and apoptosis ] ... Meanwhile, in pmikB/HeLa cells transfected with pmi kappaB, TNFalpha induced caspase 8 activation and PARP cleavage, but in the HeLa cells co-transfected with pBcl-xl and pmi kappaB, no activated caspase 8 and cleaved PARP were observed after treatment with TNFalpha
Carlson et al., Crit Care Med 2005 (Heart Diseases) : Tumor necrosis factor-alpha induced caspase activation mediates endotoxin related cardiac dysfunction
Muscari et al., Stem Cells 2005 : The effect of DFMO on TNFalpha/MG132 induced upregulation of caspase-3 activity was reversed by the addition of 100 microM putrescine, confirming that polyamines were really involved in the apoptotic process
Kim et al., Bone 2005 (MAP Kinase Signaling System) : Ghrelin also inhibited TNFalpha induced apoptosis and suppressed caspase-3 activation that occurs in response to TNFalpha as well as during in vitro differentiation process
Guicciardi et al., Gastroenterology 2005 : Pharmacological, genetic, or small interfering RNA mediated inhibition of caspase 2 attenuated tumor necrosis factor alpha mediated mitochondrial dysfunction, downstream caspase activation, and hepatocyte apoptosis
Kim et al., Biochem Biophys Res Commun 2005 (Insulinoma...) : Here, we found that : ( i ) XIAP level was inversely correlated with tumor necrosis factor (TNF)-alpha induced apoptosis in MIN6N8 insulinoma cells ; ( ii ) adenoviral XIAP overexpression abrogated the TNF-alpha induced apoptosis through inhibition of caspase activity ; ( iii ) downregulation of XIAP by antisense oligonucleotide or Smac peptide sensitized MIN6N8 cells to TNF-alpha induced apoptosis ; ( iv ) XIAP expression was induced by TNF-alpha through a nuclear factor-kappaB (NF-kappaB) dependent pathway, and interferon (IFN)-gamma prevented such an induction in a manner independent of NF-kappaB, which presents a potential mechanism underlying cytotoxic IFN-gamma/TNF-alpha synergism
Wang et al., Ann Thorac Surg 2005 (Reperfusion Injury) : Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor , interleukin-1beta and interleukin-6, and activation of caspase-1 , caspase-3 and caspase-11
Saeki et al., Biochem Biophys Res Commun 2006 : Overexpression of Monad in HEK293 cells potentiated apoptosis and caspase-3 activation induced by tumor necrosis factor-alpha and cycloheximide
Ohtani et al., FEBS Lett 2006 : In addition, 4-HC was shown to elevate TNF-alpha induced caspase-3 activation
López-Armada et al., Osteoarthritis Cartilage 2006 (Osteoarthritis) : TNF-alpha induced a gradual increase in caspase-1 and -8 mRNA levels that was not seen with IL-1beta
Liu et al., Am J Pathol 2006 (Diabetes Mellitus, Type 2) : At 21 hours, TNF-alpha inhibition significantly reduced fibroblast apoptosis and caspase-3 activity in both diabetic and normoglycemic mice ( P < 0.05 )
Diker-Cohen et al., Apoptosis 2006 (MAP Kinase Signaling System) : Inhibition of the p38 and/or the JNK death pathways reduced caspase activation induced by oxidative stress, hyperosmotic shock and TNFalpha
Saito et al., J Virol 2006 : A decrease in endogenous c-FLIP by specific small interfering RNA induced TNF-alpha mediated apoptotic cell death and caspase-8 activation
Guillermet-Guibert et al., Cell Death Differ 2007 : Importantly, sst2 sensitized NIH3T3 cells to TNFalpha induced apoptosis by ( 1 ) upregulating TNFalpha receptor protein expression, and sensitizing to TNFalpha induced caspase-8 activation ; ( 2 ) enhancing TNFalpha mediated activation of NF-kappaB, resulting in JNK inhibition and subsequent executioner caspase activation and cell death
MacRae et al., J Endocrinol 2006 : TNFalpha but not IL-1beta exposure led to increased caspase-3 activity and altered cellular morphology, consistent with reduced viability
Parsons et al., Oncogene 2006 (Cell Transformation, Neoplastic) : Taken together, these data suggest that upregulation of TMS1/ASC by TNFalpha and subsequent activation of caspase-8 could function to amplify the apoptotic signal induced by death receptors in some cell types, including breast epithelial cells
Scheuner et al., J Biol Chem 2006 : TNFalpha treatment induced eIF2alpha phosphorylation and activation of caspase 3 primarily through the dsRNA activated eIF2alpha kinase PKR
Bajaj et al., Biochem Biophys Res Commun 2006 : Caspase-12, but not caspase-9 , was activated in response to TNF-stimulation , indicating that an endoplasmic reticulum ( ER ) /calcium dependent pathway may be involved
Yim et al., J Cell Biol 2006 : Cdc6-UM expression attenuates the TNF-alpha induced activation of ATM and caspase-3 activities ... When ATM or ATR is down expressed by using the small interfering RNA technique, the TNF-alpha- or tCdc6 induced activation of caspase-3 activities is suppressed in the cells
Gyrd-Hansen et al., Mol Cell Biol 2006 : By using a large panel of genetically modified murine embryonic fibroblasts, we show here that, in response to tumor necrosis factor (TNF) , caspase-8 cleaves and activates caspase-9 in an apoptosome independent manner
Mikhaylova et al., Endocrinology 2007 : TNF-alpha increased caspase 3/7 activity ( an indicator of apoptosis ) and decreased cell viability dose and time dependently
Xu et al., Cancer Res 2006 (Breast Neoplasms) : Importantly, down-regulation of TRAIL by small interfering RNA silencing decreased TNFalpha mediated Adriamycin induced caspase activation and apoptosis, and thus enhanced breast cancer cell resistance to Adriamycin
Kulkarni et al., Apoptosis 2006 : TNF-alpha and IFN-gamma induced apoptosis in HSG cells and resulted in the activation of caspase 8 and the `` death receptor '' pathway
Sukocheva et al., J Endocrinol 2006 : T3 attenuated TNFalpha/Fas induced cleavage of caspase-8 and DNA fragmentation
Qin et al., Mol Immunol 2007 : ATD5 could also reduce the TNF-alpha mediated cytotoxicity and inhibit TNF-alpha mediated caspase activation on L929 cells in a dose dependent manner
Chang et al., Acta Pharmacol Sin 2007 (Arterial Occlusive Diseases...) : The hypoxia-inducible factor-1alpha ( HIF-1alpha ), activation of caspase-3 , and TNF-alpha mRNA transcription in ischemic regions were detected by immunoblotting and RT-PCR, respectively
Gibanova et al., Biochemistry (Mosc) 2007 : Since HLDF-6 peptide decreases the number of cells entering apoptosis caused by C ( 2 ) -ceramide, a mediator of TNF induced apoptosis, and also reduces TNF-alpha mediated activation of caspase-3 , we have proposed the hypothesis that HLDF-6 increases resistance of HL-60 cells to the TNF-alpha cytotoxic effect due to inhibition of some stages of mitochondria dependent apoptotic signaling
Prickett et al., Mol Cell Biol 2007 : Interference by alpha-4 DND or alpha-4 siRNA increased caspase 3/7 activation in response to TNF-alpha
Scheller et al., J Neural Transm Suppl 2006 : In previous studies we have reported that caspase inhibitors induce expression of various proinflammatory cytokines in CD95 stimulated primary T cells, such as TNF-alpha , IFN-gamma and GM-CSF
Zhou et al., Experimental biology and medicine (Maywood, N.J.) 2007 (Drug-Induced Liver Injury...) : Furthermore, TNF-alpha induced activations of caspase 3 and caspase 8 in the liver were significantly inhibited by zinc pretreatment
Garin et al., Circ Res 2007 : We found that PKCzeta activity was required for TNF-alpha mediated JNK and caspase-3 activation in ECs
Ahmed et al., J Vet Med Sci 2007 : However, leptin treatment increased monocyte/macrophages production of IL-1beta as well as TNF-alpha , and induced the mRNA expression of caspase-1 , which is shown to mediate the conversion of latent pro-IL-1beta and pro-IL-18 to active forms
Dey et al., J Neurochem 2007 : Pro-apoptotic caspase-3 was induced by cocaine starting at 30 min. Recombinant-TNF-alpha induced caspase-3 activity earlier than cocaine ( 15 and 20 min )
Loureiro et al., Reproduction 2007 : In some cells, however, TNF-alpha can also cause mitochondrial depolarization and caspase-9 activation ... Although TNF-alpha did not cause a measurable increase in caspase-8 activity, there was a tendency ( P = 0.07 ) for treatment of embryos with z-IETD-fmk, an inhibitor of caspase-8, to partly reduce the magnitude of the increase in TUNEL positive cells caused by TNF-alpha
Huang et al., J Biol Chem 2007 : Tumor necrosis factor-alpha (TNF) activates caspase-8 to cleave effector caspases or Bid, resulting in type-1 or type-2 apoptosis, respectively
Jain et al., FEBS J 2007 : Tumor necrosis factor-alpha induced caspase-1 gene expression ... The molecular mechanisms involved in TNF-alpha induced caspase-1 gene expression remain poorly defined, despite the fact that signaling by TNF-alpha has been well studied ... The present study was undertaken to investigate the mechanisms involved in the induction of caspase-1 gene expression by TNF-alpha ... Mutation of the interferon regulatory factor-1 binding site resulted in the almost complete loss of basal as well as of TNF-alpha induced caspase-1 promoter activity ... Our results show that TNF-alpha induces p73 gene expression, which, together with interferon regulatory factor-1, plays an important role in mediating caspase-1 promoter activation by TNF-alpha
John et al., Cytokine 2007 : Mitochondrial apoptotic inducer bax, and the suppressor bcl-2 were evaluated using western blotting at 48 h. Results indicated that TNF-alpha increased caspase activities and resulted in a significant ( p = 0.001 ) increase in bax/bcl-2 ratio ... Stimulation with IL-10 did not alter caspase activities, while co-treatment with IL-10 and TNF-alpha inhibited TNF-alpha induced caspase activities and significantly ( p > 0.004 ) impaired bax/bcl-2 ratio
Ohtsubo et al., Biochem Biophys Res Commun 2008 : Western blot analysis revealed that TNF-alpha induced activation of caspase 3 and Mst1 in a time- and dose dependent manner ... Diphenyleneiodonium, an inhibitor of NADPH oxidase, and N-acetylcysteine, a potent antioxidant, also inhibited TNF-alpha induced activation of Mst1 and caspase 3, as well as apoptosis
Stanic et al., J Cell Physiol 2008 : A longer treatment with DENSPM however reduced caspase response to TNF plus CHX
Kim et al., J Pharmacol Sci 2008 (Liver Failure) : The elevation of serum tumor necrosis factor-alpha and activation of caspase-3 were observed in the GalN/LPS group, which was attenuated by gomisin A
Li et al., J Mol Med (Berl) 2008 : Overexpression of EAPF/Phafin-2 also enhances TNF-alpha induced activity of caspase 3 ( but not caspase 8 or 9 ), and promotes TNF-alpha triggered mitochondrial membrane permeabilization ( MMP ) in L929 cells, including dissipation of mitochondrial membrane potential and release of AIF
Ogura et al., Exp Cell Res 2008 : Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates TNF-alpha mediated activation of NF-kappaB and caspase-8 ... Nevertheless, we have surprisingly found that CHX, as well as its structural analogue acetoxycycloheximide ( Ac-CHX ), prevents TNF-alpha mediated activation of NF-kappaB and caspase-8 in human lung carcinoma A549 cells ... CHX and Ac-CHX profoundly decreased constitutive and inducible expression of c-FLIP, whereas these compounds potentiated TNF-alpha induced caspase-8 activation only when metalloprotease inhibitors were present ... Thus, our results indicate that ectodomain shedding of TNF-R1 induced by protein synthesis inhibitors regulates TNF-alpha mediated activation of NF-kappaB and caspase-8
Kaushal et al., J Neurosci 2008 (Anoxia...) : The activated microglia became neurotoxic, killing naive neurons through an apoptotic mechanism that was mediated by tumor necrosis factor-alpha (TNF-alpha) , and involved activation of both caspase-8 and caspase-3
Marí et al., Gastroenterology 2008 (Disease Models, Animal...) : Unexpectedly, we observed that TNF activates caspase-8 independently of NF-kappaB inactivation, causing Bid cleavage and mitochondrial Bax oligomerization
Gustavsson et al., Retina 2008 (Diabetes Mellitus, Experimental...) : Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ), IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes induced increased expression of caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Van Themsche et al., Endocrinology 2008 (Carcinoma...) : However, XIAP small interfering RNA restored TNFalpha induced caspase signaling and apoptosis in Hec-1A cells ; XIAP small interfering RNA also increased TNFalpha induced apoptosis in Ishikawa cells
Kin et al., Shock 2008 : Compared with Control, Postcon also inhibited translocation of NF-kappa B to nuclei ( 167 % +/- 21 % vs. 142 % +/- 18 % * ), decreased the level of plasma TNF-alpha ( 1,994 +/- 447 vs. 667 +/- 130* pg/mL ), and inhibited caspase-3 activity ( 0.57 % +/- 0.1 % vs. 0.21 % +/- 0.1 % * )
Pastorino et al., J Biol Chem 2008 : Evidence is presented that tumor necrosis factor can stimulate caspase-4 and -12 activation in ethanol exposed cells, which cleaves SREBP-1 to a transcriptionally active form to induce the synthesis of lipogenic enzymes and triglycerides
Yang et al., FASEB J 2008 (Inflammation) : In addition, ST18 siRNA reduces TNF induced fibroblast apoptosis and caspase-3/7 activity
Han et al., Gut 2009 (Colitis) : STAT5b knockdown in T84 CEC increased TNFalpha dependent NF-kappaB and caspase-3 activation
Eley et al., Am J Physiol Endocrinol Metab 2008 (Muscular Atrophy) : These results suggest that TNF-alpha/IFN-gamma and ANG II induce muscle protein degradation by a common signaling pathway, which is attenuated by HMB, and that this involves the initial activation of caspase-3 and -8 , followed by autophosphorylation and activation of PKR, which then leads to increased ROS formation via activation of p38 MAPK
Moon et al., Cancer Lett 2009 (Neoplasms) : Sulforaphane suppresses TNF-alpha mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species dependent caspase-3
Tran et al., Apoptosis 2009 : Previously, employing in vitro differentiated human macrophages, we showed that following the inhibition of NF-kappaB, TNFalpha induced caspase-8 activation contributes to DNA fragmentation but is not necessary for the loss of the inner mitochondrial transmembrane potential ( DeltaPsim ) or cell death
Dhingra et al., Cardiovasc Res 2009 : Pre-exposure of cells to an IKK inhibitor ( PS-1145 ) prevented TNF-alpha induced caspase-3 and PARP cleavage
Farrell et al., J Gastroenterol Hepatol 2009 (Choline Deficiency...) : To assess extrinsic pathways, we measured hepatic expression of death inducing cytokine receptors ( tumor necrosis factor-alpha-receptor ( TNF-R)1, TNF-R2, Fas, and TNFalpha related apoptosis inducing ligand-receptor ( TRAIL-R ) mRNA, TUNEL, caspase 3 activation , liver injury and liver pathology in mice fed a methionine and choline deficient (MCD) diet
Autefage et al., J Biol Chem 2009 : CLN2-deficient cells exhibited a defect in TNF induced Bid cleavage, release of cytochrome c, and caspase-9 and -3 activation
Yu et al., Vascul Pharmacol 2009 (MAP Kinase Signaling System) : LY117018 significantly inhibited TNF-alpha induced caspase-3 activation and cell DNA fragmentation levels in bovine carotid artery endothelial cells
Tardy et al., Biochim Biophys Acta 2009 (Cell Transformation, Neoplastic...) : Finally, reconstitution of PPT1 activity in mutant cells was accompanied by resensitization to TNF induced caspase activation and toxicity
Rodella et al., Drug Metab Lett 2008 (Diabetes Mellitus, Experimental...) : Increased adiponectin levels were associated with a decrease in TNF-alpha induced ICAM-1 and VCAM-1 and caspase 3 activity in endothelial cells while phosphorylation of eNOS at Ser-1179 increased
Yao et al., Dig Liver Dis 2009 (Stomach Neoplasms) : As the molecular mechanism involved, we showed over activated Notch-1 partially suppressed TNFalpha induced activation of caspase-3
Moresi et al., PloS one 2009 : Muscle regeneration is, at least in part, regulated by caspase activation, and AVP abrogated TNF dependent caspase activation
Nakamura-López et al., Cell Biol Int 2009 : The increased TNF-alpha levels led to activation of caspase-8 by an autocrine effect via the TNF receptor expressed by the P388D1 macrophages
Badiola et al., Neurobiol Dis 2009 : In this paradigm, apoptosis depends on TNF-alpha induced activation of caspase-8 and -3 without affecting the activation of caspase-9 ... By using knock-out mice for TNF-alpha receptor 1, we show that the activation of both caspase-3 and -8 by TNF-alpha is mediated by TNF-alpha receptor 1
Sánchez-Garrido et al., Innate Immun 2009 (Choline Deficiency...) : However, PC supplementation prevented the TNF-alpha induced DNA fragmentation, cytochrome-c release and caspase-3 activity in control and CD hepatocytes
George et al., J Neurosci Res 2010 (Neuroblastoma) : Genistein triggered the receptor mediated apoptotic pathway through upregulation of TNF-alpha , FasL, TRADD, and FADD and activation of caspase-8
Guthmann et al., Exp Lung Res 2009 (Hyperoxia...) : Here, the authors show that a single subcutaneous pretreatment of rat with etanercept, a recombinant p75 TNF receptor 2 human immunoglobulin G1 ( IgG1 ) construct, inhibits the hyperoxia induced and TNFalpha mediated increase in the expression of TNFalpha receptor, the activation of caspase 3 in TII cells, and, as an early indicator of lung injury, the capillary-alveolar leakage and granulocyte number in lung lavage
Inokuchi et al., Proc Natl Acad Sci U S A 2010 (Inflammation...) : TNF-alpha increased caspase-3 activity but activated neither NF-kappaB nor JNK in Tak1-deficient hepatocytes
Marotte et al., Arthritis Rheum 2010 (Arthritis, Rheumatoid...) : Tumor necrosis factor alpha (TNFalpha) induced caspase 1 activity was determined by a colorimetric assay
Feng et al., Biochem Biophys Res Commun 2010 : Furthermore, naofen siRNA, which predominantly knocked down the expression of naofen mRNA, significantly reduced both TNF-alpha induced caspase-3 activation and apoptosis in HEK293 cells
Kayal et al., J Bone Miner Res 2010 (Diabetes Mellitus, Experimental...) : Silencing FOXO1 using siRNA in vitro significantly reduced TNF induced apoptosis and caspase activity in differentiated chondrocytes
Zou et al., Toxicology 2010 : SLD sulfide, the toxic metabolite of SLD, enhanced TNF induced cytotoxicity and caspase 3/7 activity in HepG2 cells
Harada et al., Apoptosis 2010 : Moreover, activation of caspase-3 , caspase-8 and caspase-9 induced by stimulation of TNF-a , anti-Fas or TRAIL was significantly inhibited by the knockdown of DELE expression
Ying-Wan et al., J Ethnopharmacol 2010 (Liver Failure, Acute) : Elevation of TNF-a level and activation of caspase-3 , HIF-1a were observed in the D-GalN/LPS group, which was attenuated by OC
Ussat et al., Scand J Immunol 2010 : Here, we demonstrate that in human NK cells caspase activity is required for the upregulation of select activation markers and IFN-? and TNF production, but not for cytotoxicity
Kim et al., J Ethnopharmacol 2011 (Anaphylaxis...) : Additionally, IHT inhibited the production of interleukin (IL)-6, IL-8, and TNF-a , as well as the activation of nuclear factor-?B and caspase-1 in PMACI stimulated HMC-1
Waiwut et al., Mol Cell Biochem 2011 : Gomisins A and N strongly promoted TNF-a induced cleavage of caspase-3 and PARP-1, which are key markers of apoptosis
Yang et al., Cancer Sci 2011 (Neoplasms) : In addition, wogonin suppressed the expression of the antiapoptotic factor c-FLIP, which is accompanied with potentiation of TNF induced caspase 8 activation that initiates apoptosis
Tsagarakis et al., World J Gastroenterol 2011 : TNF-a significantly increased only caspase-2
Ebmeyer et al., BMC immunology 2011 (Otitis Media) : TNFA is also required for appropriate regulation of caspase genes
Wang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011 : Reduction of MC3T3 cell surface cholesterol dramatically inhibited TNFR1 mediated AKT phosphorylation, while did not affect the degradation of I?Ba, activation of ERK or p38, and processing of caspase-3 induced by TNF-a
Ramakrishnan et al., Mol Cell 2011 : Sam68 is also found as a part of the TNF induced cytoplasmic caspase-8-FADD complex
Fauconnier et al., Proc Natl Acad Sci U S A 2011 (Myocardial Reperfusion Injury...) : TNF-a induced caspase-8 activation leads to leaky RyR2 channels that contribute to myocardial remodeling after I/R
Järvinen et al., Exp Cell Res 2011 : Further, we studied the potential involvement of the Fas- and tumor necrosis factor receptor (TNFR) mediated signaling in the activation of caspase-8 by c-Myc
Moujalled et al., Cell Death Differ 2012 : In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-?B, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-?B is required to prevent it ... By contrast, neither caspase-8 nor FLIP was required for TNF to activate p65/RelA NF-?B, because I?B was degraded, p65 translocated to the nucleus, and an NF-?B reporter gene activated normally in caspase-8 ( -/- ) or FLIP ( -/- ) MEFs ... These results show that in MEFs, caspase-8 is necessary for TNF- and FasL induced death, and FLIP is needed to prevent it, but neither caspase-8 nor FLIP is required for TNF to activate NF-?B
Xu et al., J Pharmacol Sci 2011 : Both ERK and NF-?B inhibitors decreased TNF-a induced apoptosis of EPCs, as well as the expression of cleaved caspase-3 and parp
Domitrović et al., Pharmacol Res 2012 (Disease Models, Animal...) : Additionally, in the curative regimen, oleuropein prevented tumor necrosis factor-beta1 mediated activation of hepatic stellate cells, as well as the activation of caspase-3
Stadel et al., Neoplasia (New York, N.Y.) 2011 (Pancreatic Neoplasms) : In support of this notion, inhibition of tumor necrosis factor a (TNFa) by the TNFa blocking antibody Enbrel reduces BV6- and gemcitabine induced activation of caspase 8 and 3, loss of mitochondrial membrane potential, and apoptosis
Reinecke et al., PloS one 2012 (Colitis, Ulcerative...) : XG-102 significantly reduced ( i ) pathological changes such as ulceration or crypt deformation, ( ii ) immune cell pathology such as infiltration and presence of CD3- and CD68 positive cells, ( iii ) the production of tumor necrosis factor (TNF)-a in colon tissue cultures from TNBS treated mice, ( iv ) expression of Bim, Bax, FasL, p53, and activation of caspase 3, ( v ) complexation of JNK2 and Bim, and ( vi ) expression and activation of the JNK substrate and transcription factor c-Jun
Liu et al., J Biomed Sci 2012 (Stomach Neoplasms) : The apoptosis and caspase-3 activation in response to hydrogen peroxide ( H2O2 ) or tumor necrosis factor-alpha ( TNF a ) were assessed in the presence or absence of caspase inhibitor Z-VAD-fmk
Gordon et al., Journal of neuroinflammation 2012 (Encephalitis) : TNF signaling in dopaminergic neuronal cells triggered the activation of protein kinase Cd ( PKCd ), an isoform of the novel PKC family, by caspase-3 and caspase-8 dependent proteolytic cleavage
Wang et al., International journal of clinical and experimental medicine 2012 : Myocardial rate pressure product ( RPP, LVDP*heart rate ) was markedly decreased in male hearts compared to females in exposure to TNF, which was associated with higher levels of TNF induced caspase-8 and caspase-3
Wang et al., Brain Res Bull 2012 (Hypoxia-Ischemia, Brain) : In the meanwhile, the microbubbles attenuated the production of inducible nitric oxide synthase, nitric oxide and tumor necrosis factor-alpha , as well as the activation of caspase-3 in insulted side of brain in neonatal rats
Husain et al., Invest Ophthalmol Vis Sci 2012 (Chronic Disease...) : Mechanistic data provide clues that activation of one or more opioid receptors can reduce glaucomatous-injury via suppression of TNF-a and caspase activation
Babu et al., Curr Pharm Des 2012 : TNF-a/CHX decreased cell viability, increased caspase-3/7 activity, induced apoptosis, reduced the GSH level and increased ROS production in a concentration dependent manner in MODE-K cells ... The antioxidant resveratrol abolished TNF-a/CHX induced increase in ROS production and caspase-3/7 activity, but apoptosis was only partially prevented
Park et al., Laryngoscope 2012 (MAP Kinase Signaling System) : Pretreatment with iNOS blocker NG-methyl-L-arginine ( NMA ) attenuated TNF-a induced cell death and caspase-3 activation
Rodríguez et al., Diabetologia 2012 (Diabetes Mellitus, Type 2...) : In differentiating human omental adipocytes, incubation with acylated and desacyl ghrelin reduced TNF-a induced activation of caspase-8 and caspase-3, and cell death
Bougault et al., Arthritis Rheum 2012 (Disease Models, Animal...) : We also evaluated the lipopolysaccharide (LPS)-, IL-1a-, and tumor necrosis factor a (TNFa) induced activity of matrix metalloproteinase 3 (MMP-3), MMP-9, and MMP-13 in NLRP3-knockout mice and wild-type mice and the inhibition of caspase 1 with Z-YVAD-FMK and the blockade of IL-1ß with IL-1 receptor antagonist (IL-1Ra)
Wang et al., Cancer Res 2013 : CF31 inhibition of TNF-a activation of AKT also results in TNF-a dependent activation of caspase-8 and apoptosis
Wei et al., Inflammation 2013 : When blocking intracellular CyPA by small interfering RNA in ECs, the effects of TNF-a induced EC apoptosis and proapoptotic protein caspase-3 expression were significantly inhibited
Wei et al., Purinergic signalling 2013 : NECA diminished lactate dehydrogenase ( LDH ) release, TNF-a induced increase of caspase-3 activity, and cycloheximide ( CHX ) -induced morphological changes typical of apoptosis in PC-3 cells, which were blocked by a selective A2B AR antagonist PSB603
Han et al., Mol Cancer Res 2013 (Colonic Neoplasms) : Because TNF also activates caspase-8 , selective inhibition of TNF induced extrinsic apoptosis would be required for inflammation associated tumor growth ... Furthermore, ectopic expression of the caspase-resistant, but not the wild-type, RB re-established resistance to TNF induced caspase activation in colon cancer cells without ß-catenin
Sawai et al., Biochem Biophys Res Commun 2013 (Necrosis) : TNF induced caspase-3 activity was completely inhibited by Z-VAD-fmk, Z-DEVD-fmk, or Z-Asp-CH2-DCB
Guan et al., Nan Fang Yi Ke Da Xue Xue Bao 2013 : a-Toxin induced apoptosis of HUV-EC-C cells in a dose- and time dependent manner and caused significantly enhanced expression of TNF-a and the activation of both caspase-3 and caspase-8
Yu et al., Mol Med Report 2013 : In addition, SEB and a-toxin were able to induce the expression of TNF-a and the activation of caspase-3 and -8 in the ECV304 cells
Cao et al., Zhonghua Wei Chang Wai Ke Za Zhi 2013 (Stomach Neoplasms) : PDTC can enhance the cell apoptosis induced by TNF-a, which may be associated with the blocking of TNF-a activated NF-?B signaling pathway by PDTC, the down-regulation of survivin expression, and up-regulation of caspase-3 expression
Kim et al., J Biol Chem 1997 : TNFalpha induced apoptosis and caspase-3-like activity were also reduced in cultured hepatocytes exposed to 8-bromo-cGMP, and both effects were inhibited by the cGMP dependent kinase inhibitor KT5823
Hermann et al., Arterioscler Thromb Vasc Biol 1997 : Indeed, shear stress prevented the activation of caspase-3-like activity induced by H202 or TNF alpha
Jaeschke et al., J Immunol 1998 (Disease Models, Animal...) : Furthermore, only murine TNF-alpha but not IL-1alphabeta increased caspase activity and apoptosis
Jänicke et al., J Biol Chem 1998 (Breast Neoplasms...) : These results indicate that although caspase-3 is not essential for TNF- or staurosporine induced apoptosis, it is required for DNA fragmentation and some of the typical morphological changes of cells undergoing apoptosis
Manna et al., J Biol Chem 1998 : TNF induced antiproliferative effects and caspase-3 activation, indicators of apoptosis, were also completely suppressed by transfection of cells with Mn-SOD
Mao et al., J Biol Chem 1998 (Breast Neoplasms) : Instead, tumor necrosis factor induced the translocation of pro-caspase-1 to the nucleus where it was proteolytically activated, releasing the intact prodomain
Lindenboim et al., Neurosci Lett 1998 : Our findings also showed that TNF alpha induced activation of caspase-3 is inhibited by overexpression of Bcl-xL, suggesting that Bcl-xL acts upstream of caspase activation
Pober et al., Pathol Biol (Paris) 1998 : The pathways leading to apoptosis following treatment with TNF + CHX and TNF + cer are different since only TNF + CHX is blocked by the caspase inhibitors crmA protein or the peptide zVAD.fmk while only TNF + cer is blocked by the anti apoptotic proteins Bcl-2, Bcl-XL or Al
Rai et al., Proc Natl Acad Sci U S A 1998 : Given evidence that nitric oxide can prevent TNF mediated activation of the pro-apoptotic protease caspase 3 and protect hepatocytes from cytokine mediated death, cytokine-inducible nitric oxide synthase (iNOS) may be an important hepatoprotective factor in the regenerating liver
Yamashita et al., Blood 1999 : TNF-alpha induced caspase activation was accompanied by a decrease in the ability of neutrophils to release superoxide anion ... Granulocyte-macrophage colony stimulating factor inhibited TNF-alpha induced caspase activation and apoptosis, while reversing the diminution in superoxide release