Gene interactions and pathways from curated databases and text-mining

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CASP6 — CASP7

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Allsopp et al., Cell Death Differ 2000 : Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis
Cowling et al., Cell Death Differ 2002 : Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway : absolute requirement for removal of caspase-6 prodomain
Edgington et al., Chem Biol 2012 : We also demonstrate that caspase-6 activation does not require active caspase-3/-7 , suggesting that it may autoactivate or be cleaved by other proteases