◀ Back to CDC42
CBL — CDC42
Pathways - manually collected, often from reviews:
-
NCI Pathway Database CDC42 signaling events:
CDC42/GTP complex (CDC42)
→
CBL (CBL)
(modification, collaborate)
Wu et al., Cell 2003*, Schmidt et al., Oncogene 2006, Feng et al., Nat Cell Biol 2006*
Evidence: mutant phenotype, assay
-
NCI Pathway Database CDC42 signaling events:
CDC42/GTP complex (CDC42)
→
betaPIX/CDC42/GTP/CBL complex (ARHGEF7-CBL-CDC42)
(modification, collaborate)
Wu et al., Cell 2003*, Schmidt et al., Oncogene 2006, Feng et al., Nat Cell Biol 2006*
Evidence: mutant phenotype, assay
-
NCI Pathway Database CDC42 signaling events:
CBL (CBL)
→
betaPIX/CDC42/GTP/CBL complex (ARHGEF7-CBL-CDC42)
(modification, collaborate)
Wu et al., Cell 2003*, Schmidt et al., Oncogene 2006, Feng et al., Nat Cell Biol 2006*
Evidence: mutant phenotype, assay
-
NCI Pathway Database CDC42 signaling events:
betaPIX/CDC42/GTP/CBL complex (ARHGEF7-CBL-CDC42)
→
betaPIX (ARHGEF7)
(modification, collaborate)
Wu et al., Cell 2003*, Schmidt et al., Oncogene 2006, Feng et al., Nat Cell Biol 2006*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Internalization of ErbB1:
CDC42/GTP complex (CDC42)
→
CBL (CBL)
(modification, collaborate)
Wu et al., Cell 2003*, Schmidt et al., Oncogene 2006, Feng et al., Nat Cell Biol 2006*
Evidence: mutant phenotype
-
NCI Pathway Database Internalization of ErbB1:
CDC42/GTP complex (CDC42)
→
betaPIX/CDC42/GTP/CBL complex (ARHGEF7-CBL-CDC42)
(modification, collaborate)
Wu et al., Cell 2003*, Schmidt et al., Oncogene 2006, Feng et al., Nat Cell Biol 2006*
Evidence: mutant phenotype
-
NCI Pathway Database Internalization of ErbB1:
CBL (CBL)
→
betaPIX/CDC42/GTP/CBL complex (ARHGEF7-CBL-CDC42)
(modification, collaborate)
Wu et al., Cell 2003*, Schmidt et al., Oncogene 2006, Feng et al., Nat Cell Biol 2006*
Evidence: mutant phenotype
-
NCI Pathway Database Internalization of ErbB1:
betaPIX/CDC42/GTP/CBL complex (ARHGEF7-CBL-CDC42)
→
betaPIX (ARHGEF7)
(modification, collaborate)
Wu et al., Cell 2003*, Schmidt et al., Oncogene 2006, Feng et al., Nat Cell Biol 2006*
Evidence: mutant phenotype
-
Reactome Reaction:
CBL
→
CDC42
(indirect_complex)
Wu et al., Cell 2003*, Schmidt et al., Oncogene 2006
-
Reactome Reaction:
CBL
→
CDC42
(reaction)
Wu et al., Cell 2003*, Schmidt et al., Oncogene 2006
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Feng et al., EMBO J 2004
:
The binding of either PAK ( p21 activated kinase ) or
Cbl ( Casitas B-lymphoma ) to the SH3 domain of monomeric Cool-2 is
necessary for the functional interactions between GDP bound
Cdc42 or Rac and the Cool-2 monomer
Hirsch et al., Cancer Res 2006
(Breast Neoplasms) :
These findings indicate that Cdc42 and c-Cbl are critical components involved in the regulation of EGFR protein levels and that restoration of proper EGFR degradation by disrupting
Cdc42 regulation of
c-Cbl can reduce cell proliferation and migration in MDA-MB-231 and BT20 cells