Gene interactions and pathways from curated databases and text-mining

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CBL — CDC42

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Feng et al., EMBO J 2004 : The binding of either PAK ( p21 activated kinase ) or Cbl ( Casitas B-lymphoma ) to the SH3 domain of monomeric Cool-2 is necessary for the functional interactions between GDP bound Cdc42 or Rac and the Cool-2 monomer
Hirsch et al., Cancer Res 2006 (Breast Neoplasms) : These findings indicate that Cdc42 and c-Cbl are critical components involved in the regulation of EGFR protein levels and that restoration of proper EGFR degradation by disrupting Cdc42 regulation of c-Cbl can reduce cell proliferation and migration in MDA-MB-231 and BT20 cells