◀ Back to CSF1
CBL — CSF1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lee et al., EMBO J 1999
(Cell Transformation, Neoplastic) :
Colony stimulating factor-1 (CSF-1) activation of the
CSF-1 receptor (CSF-1R) causes
Cbl protooncoprotein tyrosine phosphorylation, Cbl-CSF-1R association and their simultaneous multiubiquitination at the plasma membrane
Nakamura et al., Endocrinology 2003
:
Treatment with
M-CSF results in further tyrosine phosphorylation of both p130Cas and
c-Cbl , suggesting cooperation between alpha v beta 3 integrin and the M-CSF receptor, c-Fms, in osteoclasts ... However,
M-CSF induces tyrosine phosphorylation of
c-Cbl , but not p130Cas in pOCs in suspension, confirming the role of c-Cbl as a downstream effector of c-Fms ... In Src-deficient pOCs plated on vitronectin, although
M-CSF highly
induces Cbl phosphorylation, it does not affect p130Cas phosphorylation ... These results suggest that in osteoclasts 1 ) tyrosine phosphorylation of p130Cas depends on alpha v beta 3 integrin mediated cell adhesion, even in the presence of M-CSF ; 2 ) on the other hand,
c-Cbl phosphorylation is predominantly
activated by
M-CSF and is independent of cell adhesion ; 3 ) lastly, although c-Src is essential for both adhesion- and M-CSF mediated phosphorylation of p130Cas, it is clearly not required for c-Cbl phosphorylation in M-CSF treated pOCs
Pakuts et al., J Biol Chem 2007
:
Using murine myeloid cells expressing CSF-1R ( FD-Fms cells ), we show that SLAP-2 is tyrosine phosphorylated upon
stimulation with
CSF-1 and associates constitutively with both
c-Cbl and CSF-1R