Gene interactions and pathways from curated databases and text-mining

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CBL — CSF1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lee et al., EMBO J 1999 (Cell Transformation, Neoplastic) : Colony stimulating factor-1 (CSF-1) activation of the CSF-1 receptor (CSF-1R) causes Cbl protooncoprotein tyrosine phosphorylation, Cbl-CSF-1R association and their simultaneous multiubiquitination at the plasma membrane
Nakamura et al., Endocrinology 2003 : Treatment with M-CSF results in further tyrosine phosphorylation of both p130Cas and c-Cbl , suggesting cooperation between alpha v beta 3 integrin and the M-CSF receptor, c-Fms, in osteoclasts ... However, M-CSF induces tyrosine phosphorylation of c-Cbl , but not p130Cas in pOCs in suspension, confirming the role of c-Cbl as a downstream effector of c-Fms ... In Src-deficient pOCs plated on vitronectin, although M-CSF highly induces Cbl phosphorylation, it does not affect p130Cas phosphorylation ... These results suggest that in osteoclasts 1 ) tyrosine phosphorylation of p130Cas depends on alpha v beta 3 integrin mediated cell adhesion, even in the presence of M-CSF ; 2 ) on the other hand, c-Cbl phosphorylation is predominantly activated by M-CSF and is independent of cell adhesion ; 3 ) lastly, although c-Src is essential for both adhesion- and M-CSF mediated phosphorylation of p130Cas, it is clearly not required for c-Cbl phosphorylation in M-CSF treated pOCs
Pakuts et al., J Biol Chem 2007 : Using murine myeloid cells expressing CSF-1R ( FD-Fms cells ), we show that SLAP-2 is tyrosine phosphorylated upon stimulation with CSF-1 and associates constitutively with both c-Cbl and CSF-1R