Nebigil et al., Proc Natl Acad Sci U S A 2000
(MAP Kinase Signaling System) :
Moreover, by using the specific platelet derived growth factor receptor ( PDGFR ) inhibitor AG 1296 or by overexpressing a kinase-mutant PDGFR, we show that PDGFR kinase activity is essential for 5-HT2B triggered MAPK/cyclin D1 , but not cyclin E, signaling pathways
Guida et al., Clin Cancer Res 2007
:
Sorafenib blocked receptor autophosphorylation and signaling of KIT and PDGFRbeta gatekeeper mutants in intact cells as well as activation of AP1-responsive and cyclin D1 gene promoters, respectively