We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to FASLG

CD3D — FASLG

Text-mined interactions from Literome

Schulze-Luehrmann et al., Blood 2002 : When HPK1 was overexpressed in murine CD4 ( + ) T cells, a substantial increase was observed in spontaneous and TCR/CD3 mediated apoptosis as well as in Fas ligand (FasL) expression
Pardo et al., Int Immunol 2003 : We show in the present work that phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 prevent TCR/CD3 induced functional Fas ligand (FasL) expression, but not perforin dependent cytotoxicity ... Altogether, the results suggest that TCR/CD3 induced FasL gene transcription is controlled by PI3K and PKCtheta activation, while this signaling pathway is not implicated in CTL degranulation, which is rather dependent on the activation of classical PKC isoforms