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CD3D — FASLG
Text-mined interactions from Literome
Schulze-Luehrmann et al., Blood 2002
:
When HPK1 was overexpressed in murine CD4 ( + ) T cells, a substantial increase was observed in spontaneous and
TCR/CD3 mediated apoptosis as well as in
Fas ligand (FasL) expression
Pardo et al., Int Immunol 2003
:
We show in the present work that phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 prevent
TCR/CD3 induced functional
Fas ligand (FasL) expression, but not perforin dependent cytotoxicity ... Altogether, the results suggest that
TCR/CD3 induced
FasL gene transcription is controlled by PI3K and PKCtheta activation, while this signaling pathway is not implicated in CTL degranulation, which is rather dependent on the activation of classical PKC isoforms