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CD80 — IL4
Text-mined interactions from Literome
Oki et al., Eur J Immunol 2000
:
The Stat6 association with CD28 is specifically induced by
CD80 or CD86 ligand binding and is not
dependent upon the secretion of
IL-4 or IL-13
Rafiq et al., Clin Exp Immunol 2000
:
In accordance with this,
CD80 and phorbol myristate acetate ( PMA ) ( without anti-CD3 or calcium ionophore ) were
sufficient to induce production of IL-5 and IL-13, but not of
IL-4
Zheng et al., J Hematother Stem Cell Res 2000
:
In the
presence of GM-CSF and
IL-4 , CB-adherent cells became nonadherent, acquired DC morphology, and showed increased expression of CD1a,
CD80 , CD86, and HLA-DR ; they lost membrane CD14 and some cells with the expression of CD83 and CMRF-44 were generated
Mongini et al., Cell Immunol 2002
:
In the
presence of
IL-4 , BCR : CD21 co-ligation augmented CD86 and
CD80 expression under conditions of greater BCR engagement
Rutkowski et al., Arch Immunol Ther Exp (Warsz) 2003
(Asthma) :
CD80 and CD86 expression on LPS stimulated monocytes and the
effect of CD80 and CD86 blockade on
IL-4 and IFN-gamma production in nonatopic bronchial asthma
Blanchet et al., Am J Respir Crit Care Med 2004
(Alveolitis, Extrinsic Allergic) :
To test the effect of nicotine on alveolar macrophages, AMJ2-C11 cells were treated with nicotine and stimulated with lipopolysaccharide or Saccharopolyspora rectivirgula, a causative agent of HP. Nicotine reduced tumor necrosis factor release and tumor necrosis factor,
interleukin-10 , and IFN-gamma mRNA expression after stimulation and decreased
CD80 expression by 55 % in lipopolysaccharide stimulated cells and by 41 % in S. rectivirgula
stimulated cells
den Dekker et al., J Immunol 2008
:
IL-4 dose-dependently
up-regulated the expression of DC-specific ICAM-3 grabbing nonintegrin ( DC-SIGN ),
CD80 , CD206, and CD1a
Nguyen et al., Cytotherapy 2008
:
At a contaminating concentration of 5 Plt/MO, matured DC showed the highest expression of HLA-DR,
CD80 and CD86,
inducing a strong T-cell proliferation with high production of
IL-4 and interferon-gamma
Izawa et al., Biochem Biophys Res Commun 2010
:
Moreover, P-gp blockade, compared to controls, attenuated intragraft expression of CD3 and
CD80 , but not CD86, and
inhibited IFN-gamma and
IL-4 production ( P < 0.05 )
Vigne et al., Blood 2011
:
In addition, IL-36ß enhanced the expression of
CD80 , CD86, and MHC class II by BMDCs. IL-36 also
induced the production of IFN-?,
IL-4 , and IL-17 by CD4 ( + ) T cells and cultured splenocytes
Ranheim et al., Cell Immunol 1995
:
Tumor necrosis factor-alpha facilitates induction of
CD80 ( B7-1 ) and CD54 on human B cells by activated T cells : complex
regulation by
IL-4 , IL-10, and CD40L ...
IL-4 augments the expression of
CD80 induced by crosslinking either CD40 or CD120b
Saito et al., Eur J Immunol 1996
(Acute Disease...) :
Furthermore,
anti-CD80 + 86 mAb preferentially
inhibited the production of interferon (IFN)-gamma, but not
IL-4 and IL-10, when cultures were assayed at 21 days
Junghans et al., Exp Dermatol 1996
:
Moreover,
IL-4 induced a proliferative response in keratinocytes after 1 day of culture and
enhanced B7/BB1 expression in these cells
Zhang et al., Cell Immunol 1997
:
Both CD80 and CD86 were able to provide costimulation for interferon-gamma and IL-2 synthesis by rhesus CD4+ T cells, but
CD80 costimulation also
resulted in synthesis of
IL-4 and IL-10
Behrens et al., J Immunol 1998
(Muscular Dystrophies...) :
Stimulation of myoblasts with
IL-4 induces B7.1 and B7.2, as well as
BB-1 , but with different time kinetics
Möttönen et al., Br J Rheumatol 1998
(Arthritis, Rheumatoid) :
IL-4 + GM-CSF, a combination of cytokines known to induce differentiation of dendritic cells,
increased the expression of CD40,
CD80 and CD86, and decreased the expression of CD14 on SF macrophages