Gene interactions and pathways from curated databases and text-mining

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CD80 — IL4

Text-mined interactions from Literome

Oki et al., Eur J Immunol 2000 : The Stat6 association with CD28 is specifically induced by CD80 or CD86 ligand binding and is not dependent upon the secretion of IL-4 or IL-13
Rafiq et al., Clin Exp Immunol 2000 : In accordance with this, CD80 and phorbol myristate acetate ( PMA ) ( without anti-CD3 or calcium ionophore ) were sufficient to induce production of IL-5 and IL-13, but not of IL-4
Zheng et al., J Hematother Stem Cell Res 2000 : In the presence of GM-CSF and IL-4 , CB-adherent cells became nonadherent, acquired DC morphology, and showed increased expression of CD1a, CD80 , CD86, and HLA-DR ; they lost membrane CD14 and some cells with the expression of CD83 and CMRF-44 were generated
Mongini et al., Cell Immunol 2002 : In the presence of IL-4 , BCR : CD21 co-ligation augmented CD86 and CD80 expression under conditions of greater BCR engagement
Rutkowski et al., Arch Immunol Ther Exp (Warsz) 2003 (Asthma) : CD80 and CD86 expression on LPS stimulated monocytes and the effect of CD80 and CD86 blockade on IL-4 and IFN-gamma production in nonatopic bronchial asthma
Blanchet et al., Am J Respir Crit Care Med 2004 (Alveolitis, Extrinsic Allergic) : To test the effect of nicotine on alveolar macrophages, AMJ2-C11 cells were treated with nicotine and stimulated with lipopolysaccharide or Saccharopolyspora rectivirgula, a causative agent of HP. Nicotine reduced tumor necrosis factor release and tumor necrosis factor, interleukin-10 , and IFN-gamma mRNA expression after stimulation and decreased CD80 expression by 55 % in lipopolysaccharide stimulated cells and by 41 % in S. rectivirgula stimulated cells
den Dekker et al., J Immunol 2008 : IL-4 dose-dependently up-regulated the expression of DC-specific ICAM-3 grabbing nonintegrin ( DC-SIGN ), CD80 , CD206, and CD1a
Nguyen et al., Cytotherapy 2008 : At a contaminating concentration of 5 Plt/MO, matured DC showed the highest expression of HLA-DR, CD80 and CD86, inducing a strong T-cell proliferation with high production of IL-4 and interferon-gamma
Izawa et al., Biochem Biophys Res Commun 2010 : Moreover, P-gp blockade, compared to controls, attenuated intragraft expression of CD3 and CD80 , but not CD86, and inhibited IFN-gamma and IL-4 production ( P < 0.05 )
Vigne et al., Blood 2011 : In addition, IL-36ß enhanced the expression of CD80 , CD86, and MHC class II by BMDCs. IL-36 also induced the production of IFN-?, IL-4 , and IL-17 by CD4 ( + ) T cells and cultured splenocytes
Ranheim et al., Cell Immunol 1995 : Tumor necrosis factor-alpha facilitates induction of CD80 ( B7-1 ) and CD54 on human B cells by activated T cells : complex regulation by IL-4 , IL-10, and CD40L ... IL-4 augments the expression of CD80 induced by crosslinking either CD40 or CD120b
Saito et al., Eur J Immunol 1996 (Acute Disease...) : Furthermore, anti-CD80 + 86 mAb preferentially inhibited the production of interferon (IFN)-gamma, but not IL-4 and IL-10, when cultures were assayed at 21 days
Junghans et al., Exp Dermatol 1996 : Moreover, IL-4 induced a proliferative response in keratinocytes after 1 day of culture and enhanced B7/BB1 expression in these cells
Zhang et al., Cell Immunol 1997 : Both CD80 and CD86 were able to provide costimulation for interferon-gamma and IL-2 synthesis by rhesus CD4+ T cells, but CD80 costimulation also resulted in synthesis of IL-4 and IL-10
Behrens et al., J Immunol 1998 (Muscular Dystrophies...) : Stimulation of myoblasts with IL-4 induces B7.1 and B7.2, as well as BB-1 , but with different time kinetics
Möttönen et al., Br J Rheumatol 1998 (Arthritis, Rheumatoid) : IL-4 + GM-CSF, a combination of cytokines known to induce differentiation of dendritic cells, increased the expression of CD40, CD80 and CD86, and decreased the expression of CD14 on SF macrophages