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CDC25A — CDKN1A
Text-mined interactions from Literome
Jaime et al., Hepatology 2002
:
Thus, the results reported here indicate that
p21 ( Cip1 )
regulates the levels and the intracellular localization of
CDC25A
Ray et al., Mol Cancer Ther 2007
(Prostatic Neoplasms) :
Cdc25A dependent regulation of cyclin dependent kinase 2 (Cdk2) and changes in association of
p21 ( WAF1/CIP1 ) and hSpy1 with Cdk2 resulted in inhibition of Cdk2 associated kinase activity
Ozmen et al., Phytomedicine 2010
(Leukemia, Promyelocytic, Acute) :
The strongest anti-leukemic activity was shown by the methanol extract, which contained apigenin, baicalein, chrysin, luteolin and wogonin, with an IpC50 of 43 microg/ml ( corresponding to 1.3mg/ml of dried plant material ) which correlated with cyclin D1- and
Cdc25A suppression and
p21 induction
Chiu et al., Anticancer Res 2009
(Carcinoma, Squamous Cell...) :
Treatment with 30 microM of aloe-emodin led to S-phase arrest through promoted p53,
p21 and p27, but
inhibited cyclin A, E, thymidylate synthase and
Cdc25A levels
de Carné Trécesson et al., J Biol Chem 2011
:
We also observed that
p21 ( WAF1 )
prevents the expression of the
CDC25A and PLK1 genes to induce cell cycle arrest
Foskolou et al., Oncogene 2013
(Neuroblastoma) :
Most importantly, Prox1 was sufficient to decrease
Cdc25A and
induce p27-Kip1, but not
p21-Cip1 or p53
Coqueret et al., EMBO J 1998
:
Moreover,
p21WAF1/CIP1/SDI1 expression was
repressed equally well by either
Cdc25A or Cut