Gene interactions and pathways from curated databases and text-mining

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CDC25A — CDKN1A

Text-mined interactions from Literome

Jaime et al., Hepatology 2002 : Thus, the results reported here indicate that p21 ( Cip1 ) regulates the levels and the intracellular localization of CDC25A
Ray et al., Mol Cancer Ther 2007 (Prostatic Neoplasms) : Cdc25A dependent regulation of cyclin dependent kinase 2 (Cdk2) and changes in association of p21 ( WAF1/CIP1 ) and hSpy1 with Cdk2 resulted in inhibition of Cdk2 associated kinase activity
Ozmen et al., Phytomedicine 2010 (Leukemia, Promyelocytic, Acute) : The strongest anti-leukemic activity was shown by the methanol extract, which contained apigenin, baicalein, chrysin, luteolin and wogonin, with an IpC50 of 43 microg/ml ( corresponding to 1.3mg/ml of dried plant material ) which correlated with cyclin D1- and Cdc25A suppression and p21 induction
Chiu et al., Anticancer Res 2009 (Carcinoma, Squamous Cell...) : Treatment with 30 microM of aloe-emodin led to S-phase arrest through promoted p53, p21 and p27, but inhibited cyclin A, E, thymidylate synthase and Cdc25A levels
de Carné Trécesson et al., J Biol Chem 2011 : We also observed that p21 ( WAF1 ) prevents the expression of the CDC25A and PLK1 genes to induce cell cycle arrest
Foskolou et al., Oncogene 2013 (Neuroblastoma) : Most importantly, Prox1 was sufficient to decrease Cdc25A and induce p27-Kip1, but not p21-Cip1 or p53
Coqueret et al., EMBO J 1998 : Moreover, p21WAF1/CIP1/SDI1 expression was repressed equally well by either Cdc25A or Cut