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CDC42 — PI3
Text-mined interactions from Literome
Chen et al., J Biol Chem 2004
(Cryptosporidiosis) :
Here, we tested the
role of
phosphatidylinositol 3-kinase (PI3K) and frabin, a guanine nucleotide exchange factor specific for Cdc42 in the activation of
Cdc42 during C. parvum infection of biliary epithelial cells
Jin et al., Neurochem Int 2007
:
These results suggest that the NGF induced ruffling requires activation of Rac1 and
Cdc42 , but does not
require Ras,
PI-3k , Akt and GSK-3beta
Bosse et al., Mol Cell Biol 2007
:
Moreover,
Cdc42 activation was fully
independent of
PI3-kinase activity, whereas the latter partly depended on Cdc42
Beemiller et al., Mol Biol Cell 2010
:
Fcgamma Receptor ( FcR ) -mediated phagocytosis by macrophages requires
phosphatidylinositol 3-kinase (PI3K) and
activation of the Rho-family GTPases
Cdc42 and Rac1
Kim et al., Exp Mol Med 2012
(Diabetes Mellitus, Experimental...) :
The
phosphoinositide 3-kinase (PI3K) inhibitor, wortmannin, simultaneously
regulates Rac1 and
Cdc42 , which destabilize the podocyte actin cytoskeleton during early DN
Zheng et al., J Biol Chem 1994
:
In addition,
PI 3-kinase activity immunoprecipitated from cell lysates with anti-p85 antibody was
stimulated 2-4-fold by
GST-Cdc42-GTP gamma S. Similar interactions were observed between p85 and GST-Rac1-GTP gamma S but not between p85 and GST-RhoA-GTP gamma S ... These findings suggest that
PI 3-kinase , through the Rho-GAP homology domain of p85, can couple to the effector domain of Cdc42Hs and that p85 may be a
target for the GTP bound forms of
Cdc42Hs and Rac1