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CDK6 — CNTN2
Text-mined interactions from Literome
Haller et al., AIDS Res Hum Retroviruses 2000
:
In T cells and fibroblasts
Tax enhances the activity of the cyclin dependent kinases (CDK) CDK4 and
CDK6
Zhi et al., PLoS Pathog 2011
:
Paradoxically, expression of
Tax in most cells
leads to drastic up-regulation of
cyclin dependent kinase inhibitors, p21 ( CIP1/WAF1 ) and p27 ( KIP1 ), which cause p53-/pRb independent cellular senescence
Schmitt et al., J Virol 1998
(Cell Transformation, Neoplastic) :
In the
presence of
Tax , both Cdk4 and
Cdk6 were activated ... The suppression of
Tax synthesis, however,
resulted in a significant reduction of the Cdk4 and
Cdk6 activities but did not influence the expression of Cdk4, Cdk6, or cognate D-type cyclin proteins ... These data suggest that
Tax induces Cdk4 and
Cdk6 activity in primary human T lymphocytes ; this Cdk activation is likely to account for the mitogenic Tax effect and for the abnormal T-cell proliferation of HTLV-1 infected lymphocytes