Gene interactions and pathways from curated databases and text-mining

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CDK6 — CNTN2

Text-mined interactions from Literome

Haller et al., AIDS Res Hum Retroviruses 2000 : In T cells and fibroblasts Tax enhances the activity of the cyclin dependent kinases (CDK) CDK4 and CDK6
Zhi et al., PLoS Pathog 2011 : Paradoxically, expression of Tax in most cells leads to drastic up-regulation of cyclin dependent kinase inhibitors, p21 ( CIP1/WAF1 ) and p27 ( KIP1 ), which cause p53-/pRb independent cellular senescence
Schmitt et al., J Virol 1998 (Cell Transformation, Neoplastic) : In the presence of Tax , both Cdk4 and Cdk6 were activated ... The suppression of Tax synthesis, however, resulted in a significant reduction of the Cdk4 and Cdk6 activities but did not influence the expression of Cdk4, Cdk6, or cognate D-type cyclin proteins ... These data suggest that Tax induces Cdk4 and Cdk6 activity in primary human T lymphocytes ; this Cdk activation is likely to account for the mitogenic Tax effect and for the abnormal T-cell proliferation of HTLV-1 infected lymphocytes