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APOB — CETP

Pathways - manually collected, often from reviews:

• Reactome Reaction: APOB → CETP (reaction) Qiu et al., Nature structural & molecular biology 2007*, Lagor et al., Arterioscler Thromb Vasc Biol 2009*, Lagor et al., PloS one 2012*, Swenson et al., J Biol Chem 1988*, Morton et al., J Biol Chem 1983*, Wang et al., J Biol Chem 1999*

Text-mined interactions from Literome

De Roos et al., J Intern Med 2000 : To determine the long-term effects of unfiltered coffee consumption on the activity levels of cholesteryl ester transfer protein ( CETP ), phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase ( LCAT ) and to assess a possible role of CETP activity levels in the rise in serum LDL cholesterol
Carrilho et al., Lipids 2001 (Dwarfism, Pituitary) : The simultaneous decrease of the plasma CETP and LDL-C concentrations elicited by hrGH indicated a close relationship between LDL metabolism and the regulation of the CETP gene expression
Paromov et al., J Biol Chem 2003 : CETP has no apparent preference for high ( HDL ) or low ( LDL ) density lipoprotein as lipid donor to very low density lipoprotein ( VLDL ), and the preference for HDL observed in plasma is due to suppression of LDL transfers by lipid transfer inhibitor protein (LTIP)
Brousseau et al., N Engl J Med 2004 : In subjects with low HDL cholesterol levels, CETP inhibition with torcetrapib markedly increased HDL cholesterol levels and also decreased LDL cholesterol levels, both when administered as monotherapy and when administered in combination with a statin
Takata et al., Clin Sci (Lond) 2006 (Coronary Artery Disease...) : CETP ( cholesteryl ester transfer protein ) and HL ( hepatic lipase ) play a role in the metabolism of plasma lipoproteins, but the effects of CETP and LIPC ( gene encoding HL ) genotypes on coronary atherosclerosis may be dependent on LDL ( low-density lipoprotein)-receptor activity
Inazu et al., Atherosclerosis 2008 : CETP deficiency results in low LDL and high HDL phenotype including apoE-rich large HDL
Hall et al., Biochem Soc Trans 2011 (Cardiovascular Diseases) : In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis
Kurushima et al., Biochim Biophys Acta 1995 : These results suggest that dietary oleic acid inhibits the increases in total, VLDL-, and LDL-cholesterol induced by dietary cholesterol by preventing both LDL receptor suppression and increased CETP activity, whereas dietary palmitic acid augments the cholesterol induced increases in total and LDL-cholesterol by both further suppression of LDL receptor activity and further stimulation of CETP activity
van Tol et al., Atherosclerosis 1995 : We conclude that the increased activity of CETP may contribute to the rise in LDL cholesterol and the fall in HDL cholesterol seen on diets with high contents of trans fatty acids
Evans et al., J Lipid Res 1994 (Disease Models, Animal...) : Inhibition of CETP activity resulted in a decrease in both low density lipoprotein (LDL) and very low density lipoprotein ( VLDL ) cholesterol concomitant with HDL increase, and in hypercholesterolemic animals resulted in increased total serum cholesterol
Jiang et al., J Biol Chem 1993 : The accumulation of lipoprotein B particles results from CETP mediated down-regulation of liver LDL receptors, possibly due to enhanced return of cholesterol to the liver