◀ Back to FAS
CFLAR — FAS
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of CFLAR-KRT18-KRT8-RAF1
→
FAS
(increases)
Gilbert et al., Mol Cell Biol 2004*
Evidence: c-Flip, along with Raf-1, is part of a K8/K18-immunoisolated complex from wild-type hepatocytes, and Fas stimulation leads to further c-Flip and Raf-1 recruitment in the complex.
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG)
→
I-FLICE (CFLAR)
(modification, activates)
-
BioCarta fas signaling pathway (cd95):
I-FLICE/RIP2 complex (CFLAR-RIPK2)
→
FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10)
(modification, activates)
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR)
→
Caspase 10 (CASP10)
(modification, collaborate)
Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR)
→
c-FLIP (CFLAR)
(modification, collaborate)
Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, collaborate)
Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD/CASP10/CASP10 complex (FAS-FASLG-FADD-CASP10)
(modification, collaborate)
Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR)
→
Caspase 10 p12 (CASP10)
(modification, collaborate)
Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP10 p23/17/c-FLIPL p43 complex (FAS-FASLG-FADD-CASP10-CFLAR)
→
c-FLIPL p12 (CFLAR)
(modification, collaborate)
Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIP (CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, collaborate)
Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIP (CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD/CASP10/CASP10 complex (FAS-FASLG-FADD-CASP10)
(modification, collaborate)
Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
→
c-FLIPL p12 (CFLAR)
(modification, collaborate)
Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP10/CASP10 complex (FAS-FASLG-FADD-CASP10)
→
c-FLIPL p12 (CFLAR)
(modification, collaborate)
Wang et al., Proc Natl Acad Sci U S A 2001, Chang et al., EMBO J 2002, Vincenz et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIP (CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1)
(modification, inhibits)
Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIP (CFLAR)
→
FASLG/FAS (trimer) complex (FAS-FASLG)
(modification, inhibits)
Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
cIAP1-2 (BIRC2/BIRC3)
→
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
(modification, inhibits)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
cIAP1-2 (BIRC2/BIRC3)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, inhibits)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 (CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 (CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8)
→
c-FLIP (CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8)
→
c-FLIP p12 (CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIP (CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIP (CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIP (CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 p10 (CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 p10 (CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
→
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
→
c-FLIP p12 (CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
→
c-FLIP p12 (CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
→
c-FLIP p12 (CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIPS (CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8/c-FLIPS complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIPS (CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, collaborate)
Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 (CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8/c-FLIPS complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8/c-FLIPS complex (FAS-FASLG-FADD-CASP8-CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, collaborate)
Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
c-FLIP (CFLAR)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, inhibits)
Medema et al., EMBO J 1997
-
Reactome Reaction:
FAS
→
CFLAR
(indirect_complex)
Siegmund et al., J Biol Chem 2001, Micheau et al., Mol Cell Biol 2001*, Micheau et al., J Biol Chem 2002*, Kreuz et al., J Cell Biol 2004, Kim et al., Journal of molecular signaling 2008*, Fricker et al., J Cell Biol 2010*, Pop et al., Biochem J 2011*, Scaffidi et al., J Biol Chem 1999
-
Reactome Reaction:
FAS
→
CFLAR
(reaction)
Siegmund et al., J Biol Chem 2001, Micheau et al., Mol Cell Biol 2001*, Micheau et al., J Biol Chem 2002*, Kreuz et al., J Cell Biol 2004, Kim et al., Journal of molecular signaling 2008*, Fricker et al., J Cell Biol 2010*, Pop et al., Biochem J 2011*, Scaffidi et al., J Biol Chem 1999
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
FAS
—
CFLAR
(physical association, affinity chromatography technology)
Shu et al., Immunity 1997*
-
IRef Biogrid Interaction:
FAS
—
CFLAR
(physical association, affinity chromatography technology)
MacFarlane et al., J Biol Chem 1997
-
MIPS CORUM Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced:
Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced complex (CASP8-CFLAR-FADD-FAS)
Lavrik et al., J Biol Chem 2008
-
IRef Hprd Interaction:
Complex of 17 proteins
MacFarlane et al., J Biol Chem 1997
-
IRef Intact Interaction:
Complex of FADD-FAS-CFLAR-CASP8
(association, anti bait coimmunoprecipitation)
Tao et al., Blood 2011
-
IRef Intact Interaction:
Complex of FAS-CFLAR-CFLAR-FAS
(association, anti bait coimmunoprecipitation)
Tao et al., Blood 2011
-
IRef Intact Interaction:
Complex of CFLAR-FAS-CASP8-CFLAR-FAS-CASP8
(association, anti bait coimmunoprecipitation)
Shatnyeva et al., PloS one 2011*
-
IRef Intact Interaction:
Complex of 17 proteins
(association, anti bait coimmunoprecipitation)
Tao et al., Blood 2011
Text-mined interactions from Literome
Hyer et al., Cancer Biol Ther 2002
(Prostatic Neoplasms) :
These data suggest that
c-FLIP may play a critical role in regulating Fas mediated apoptosis in prostate cancer cells and that modulation of c-FLIP may
enhance Fas signaling based therapies
Gilbert et al., Mol Cell Biol 2004
(MAP Kinase Signaling System) :
c-Flip, along with Raf-1, is part of a K8/K18 immunoisolated complex from wild-type hepatocytes, and
Fas stimulation
leads to further
c-Flip and Raf-1 recruitment in the complex
Park et al., Mol Cancer Ther 2008
(Carcinoma, Hepatocellular...) :
Mitogen activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of
c-FLIP-s levels and
activation of
CD95
García et al., Rheumatology (Oxford) 2009
(Arthritis, Rheumatoid) :
Inhibition of PI3K/Akt pathway did not modify the difference between PARP-1-competent or -deficient FLS in
Fas mediated apoptosis or
c-FLIP-S expression
Walker et al., Mol Pharmacol 2009
(Colonic Neoplasms) :
In SW480 cells, sorafenib + vorinostat increased
CD95 plasma membrane levels and promoted death inducing signal complex ( DISC ) formation, and drug toxicity was
blocked by knockdown of CD95 or overexpression of
cellular FLICE-like inhibitory protein ( c-FLIP-s )
Kavuri et al., J Biol Chem 2011
:
cFLIP mediated inhibition of
CD95 and TRAIL DR could be of crucial importance during keratinocyte skin carcinogenesis and for the activation of innate and/or adaptive immune responses triggered by DR activation in the skin