Gene interactions and pathways from curated databases and text-mining

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CNR2 — NOS2

Text-mined interactions from Literome

Hillard et al., FEBS Lett 1999 : Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity
Esposito et al., J Biol Chem 2002 (Glioma) : The CB(1) and CB(2) agonist WIN 55,212-2 inhibited the expression of inducible NO synthase (iNOS) and NO release caused by treatment of C6 cells with HIV-1 Tat and interferon-gamma (IFN-gamma)
O'Sullivan et al., Eur J Pharmacol 2009 : The vascular effects of cannabidiol were not affected by endothelial denudation, nitric oxide synthase inhibition , pertussis toxin, cannabinoid CB1 or cannabinoid CB2 receptor antagonism, or capsaicin pre-treatment
Oddi et al., J Mol Med (Berl) 2012 (Brain Injuries) : Distinct regulation of nNOS and iNOS by CB2 receptor in remote delayed neurodegeneration
Ribeiro et al., Prostaglandins Other Lipid Mediat 2013 : In this study we observed that the CB1 and CB2 receptor non-selective or selective agonists dramatically attenuate iNOS induction and ROS generation in LPS activated microglia