Rubí et al., Biochem J 2002
:
Pancreatic beta-cells chronically exposed to fatty acids show higher carnitine palmitoyltransferase I (CPT I) protein levels, higher palmitate oxidation rates and an altered insulin response to glucose ... We examined the effect of increasing CPT I levels on insulin secretion in cultured beta-cells ... These results provide further evidence that CPT I activity regulates insulin secretion in the beta-cell
de Barros Reis et al., J Nutr Biochem 2008
(Malnutrition) :
These results provide further evidence that increased L-CPT-1 activity and changes in gene expression in pancreatic islets may be involved in the reduced insulin secretion seen in malnourished rats
Park et al., Biochem J 1995
(Diabetes Mellitus, Experimental...) :
These results suggest that insulin regulates CPT-I by inhibiting transcription of the CPT-I gene
Chatelain et al., Eur J Biochem 1996
:
We conclude that the rapid increase in hepatic CPT I mRNA level that accompanies the fetal to neonatal transition in the rat is triggered by the reciprocal change in circulating insulin and LCFA concentrations, coupled with elevation of the liver content of cAMP