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CRK — NOS2
Text-mined interactions from Literome
Feng et al., J Immunol 1999
:
However, studies using inhibitors selective for ERK ( PD98059 ) and p38 ( SB203580 ) show that while
p38 plays an essential role in the induction of
inducible NO synthase , ERK MAP kinases play only a minor role in promoting NO generation
Won et al., Brain Res Mol Brain Res 2001
(Glioma) :
The dose dependent inhibition of NO production and iNOS mRNA expression by compound SB203580 ( p38 inhibitor ) suggests the
participation of
p38 in PKA dependent inhibition of LPS induced NO production and
iNOS mRNA expression
Liu et al., J Cell Biochem 2001
:
Pretreatment with the potent PI3 kinase inhibitor wortmannin, the NF-kappaB inhibitor PDTC or the specific p38 MAP kinase inhibitor SB203580 each partially attenuated the induction of iNOS and NO production, demonstrating that both
p38 activation and IkappaB phosphorylation are
required for
iNOS expression
Lui et al., Am J Physiol Cell Physiol 2004
:
We show that whereas
p38gamma and -delta
had minimal effects on
iNOS expression, p38alpha and -beta2 significantly altered its expression ...
p38alpha mutant and p38beta2 wild-type dose dependently
inhibited IL-1beta induced
iNOS expression
Méndez-Samperio et al., J Infect 2004
(MAP Kinase Signaling System) :
In contrast, studies using inhibitors selective for ERK1/2 and p38 showed that
p38 plays an essential role in the induction of
NOS2 , whereas the role of ERK1/2 was minor
Liu et al., Arthritis Rheum 2004
:
MSU induced MMP-3 and
iNOS expression and NO release in chondrocytes in a
p38 dependent manner that did not require interleukin-1 (IL-1), as demonstrated by using IL-1 receptor antagonist
Kao et al., Immunology 2005
:
In this study, we further investigated the
roles of tyrosine kinase, phosphatidylinositiol 3-kinase (PI3K)/Akt, and
p38 mitogen activated protein kinase ( MAPK ) in LTA induced
iNOS expression and NO release in RAW 264.7 macrophages ... Tyrosine kinase inhibitors ( genistein and tyrphostin AG126 ), PI3K inhibitors ( wortmannin and LY 294002 ), and a
p38 MAPK inhibitor ( SB 203580 )
attenuated LTA induced
iNOS expression and NO release in concentration dependent manners
Jeon et al., J Ethnopharmacol 2006
:
Collectively, this series of experiments indicates that KIOM
inhibits iNOS gene expression by blocking NF-kappa/Rel and
p38 kinase signaling
Lee et al., Glia 2007
(Demyelinating Diseases...) :
The activation of NF-kappaB,
p38 , JNK, and dsRNA dependent protein kinase is
required for dsRNA mediated
iNOS gene expression
Sung et al., Acta Anaesthesiol Taiwan 2007
(Hyperalgesia) :
I.t. pretreatment of IL-1 receptor antagonist (IL-1ra), p38 MAPK inhibitor or iNOS inhibitor, inhibits the i.t. IL-1beta induced NO levels and thermal hyperalgesia in rats, likely via either inhibiting the IL-1beta mediated
p38 MAPK activation and subsequent
iNOS induction , or direct attenuation of the central iNOS activity, which therefore reduces the central sensitization of inflammatory pain
Sommer et al., Vet Immunol Immunopathol 2009
:
In uninfected cells, inhibition of MAPK revealed that CD40L mediated increase in IL-6 gene expression was dependent on activation of ERK1/2, while increases in IL-12p40,
iNOS , and IL-10 gene expression were
dependent on activation of
p38
Kim et al., J Periodontol 2009
:
Specific inhibitors of
p38 , extracellular signal regulated kinase ( ERK ), and c-Jun N-terminal kinase (JNK) mitogen activated protein kinases phosphatidylinositol 3-kinase (PI3K), nuclear factor-kappa B (NF-kappaB), and protein kinase C delta (PKC-delta) greatly
reduced the levels of
iNOS and HO-1 expression induced by LPS plus cytokines
Li et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2010
:
Collectively, the results of the series of experiments indicate that magnolol
inhibits iNOS gene expression by blocking NF-?B/Rel and
p38 kinase signaling
Simsek et al., Andrologie 2012
(Varicocele) :
The aim of this study was to investigate
p38-mitogene activated protein kinase ( p38-MAPK ), nuclear factor-kappa B ( p65-NF-kB ) and
inducible nitric oxide synthase (iNOS) expression in an experimental model of varicocele in the rat testis
Harbrecht et al., Am J Physiol Gastrointest Liver Physiol 2012
(MAP Kinase Signaling System) :
However, insulin did not increase p38 activation and inhibition of
p38 signaling with a dominant negative p38 plasmid
had no effect on cytokine- or insulin mediated effects on
iNOS
Chao et al., Connect Tissue Res 2012
(Inflammation...) :
Centrifugal force at 67.1 g/cm ( 2 ) for 60 min significantly increases the production of prostaglandin E2 and nitric oxide as well as gene expression of proinflammatory cytokines, including interleukin (IL)-1a, IL-1ß and IL-6, showed that centrifugal force dependent induction of cyclooxygense-2 and
inducible NO synthase required JNK and
p38 mitogen activated protein kinase, but not ERK 1/2 activities
Kleinert et al., Br J Pharmacol 1998
(Colonic Neoplasms) :
7. These results suggest that activation of
NOS II expression in DLD-1 cells is
independent of the activities of protein kinases A, C and G, phosphatidylinositol 3-kinase, extracellular signal regulated kinase and
p38 mitogen activated protein kinase, but seems to require protein tyrosine kinase activity, especially the interferon-gamma activated janus kinase 2