Gene interactions and pathways from curated databases and text-mining

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CRK — SGK1

Pathways - manually collected, often from reviews:

  • WikiPathways Insulin Signaling: GSK3B/AKT2/AKT1/SGK3/SGK1/GSK3A/PDPK1/SGK2 → STXBP2/CYTH3/KIF5B/EHD2/ARF6/RAB4A/CAP1/STXBP1/CRK/STXBP4/TBC1D4/SH2B2/EHD1/ARHGAP33/STX4/SNAP25/RHOQ/SNAP23/CBLB/STXBP3/CBL/FLOT2/CBLC/MYO1C/RHOJ/SORBS1/ARF1/RAPGEF1/VAMP2/FLOT1/KIF3A (activation)

Text-mined interactions from Literome

BelAiba et al., Circ Res 2006 (Hypertension, Pulmonary) : These data show that thrombin potently induces Sgk-1 involving NADPH oxidases, phosphatidylinositol 3-kinase, p38 mitogen activated protein kinase, and phosphoinositide dependent kinase-1, and that activation of nuclear factor kappaB by Sgk-1 mediates TF expression and activity by thrombin
Cheng et al., Circ Res 2010 (Carotid Artery Injuries...) : The mechanism for the SGK-1 expression involved MEK1 but not p38 or JNK signaling pathway