Gene interactions and pathways from curated databases and text-mining

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CRKL — IL3

Text-mined interactions from Literome

Chin et al., Biochem Biophys Res Commun 1997 : Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells ... The present study demonstrates that erythropoietin (Epo) and IL-3 induce tyrosine phosphorylation of the SH2/SH3 containing adapter protein CrkL and its transient association with tyrosine phosphorylated SHP-2, Shc, and Cbl in a murine IL-3 dependent cell line, 32D, expressing the Epo receptor (EpoR)
Ozaki et al., Blood 1998 : Furthermore, interleukin-3 (IL-3), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and erythropoietin also induce Crkl-STAT5 complex formation in responding cells in a stimulation dependent manner ... These results indicate that thrombopoietin, IL-3 , GM-CSF, and erythropoietin commonly induce association of STAT5 and Crkl and that the complex translocates to the nucleus and binds to DNA