Gene interactions and pathways from curated databases and text-mining

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CSF2 — MMP1

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Sugimoto et al., Int J Cancer 2001 (Carcinoma, Squamous Cell...) : Moreover, MMP-2 activity of G-CSFR-transfectant T3M-1 cells was enhanced by the stimulation with rG-CSF , as assessed by gelatin zymography
Ardans et al., J Leukoc Biol 2002 : However, in the presence of tumor necrosis factor (TNF)-alpha and GM-CSF , ox-LDL enhanced MMP-1 significantly by two- to threefold, increased MMP-9 slightly, and had no effect on TIMP-1 production ... In contrast, HDL suppressed the induction of MMP-1 by TNF-alpha and GM-CSF as well as the ox-LDL mediated increase in MMP-1 production
Zhou et al., J Biol Chem 2003 : Tumor necrosis factor-alpha (TNFalpha) and granulocyte macrophage colony stimulating factor ( GM-CSF ) individually enhance monocyte matrix metalloproteinase-9 (MMP-9) but induce MMP-1 only when added in combination ... IFNgamma alone did not stimulate monocyte MMP-9 or MMP-1 ; however, in the presence of GM-CSF it induced MMP-1 and enhanced MMP-1 stimulated by GM-CSF and TNFalpha ... IFNgamma induced MMP-1 in the presence of GM-CSF through the stimulation of TNFalpha production through a mechanism involving both p38 and ERK1/2 MAPKs, in which GM-CSF stimulated ERK1/2 whereas IFNgamma activated p38 ... In support of this conclusion TNFalpha neutralizing antibody and antibodies against TNF receptor I and -II blocked the induction of MMP-1 by GM-CSF and IFNgamma
Kohno et al., Pathol Int 2004 : GM-CSF activates RhoA, integrin and MMP expression in human monocytic cells ... In contrast, only GM-CSF enhanced the expression of MMP-1 and MMP-9
Zhang et al., J Leukoc Biol 2006 (Coronary Artery Disease) : Although CRP or ox-LDL failed to induce MMP-1 in control monocytes, these molecules enhanced MMP-1 production induced by tumor necrosis factor alpha (TNF-alpha) and granulocyte macrophage-colony stimulating factor ( GM-CSF ) with a synergistic increase in MMP-1 occurring in the presence of both mediators
Lim et al., PloS one 2013 : The expressions of HAS-2, tropoelastin, MMP-1 , HGF, and c-Met mRNA were significantly increased by GM-CSF , although at different time points ( P < 0.05 )
Tsuruta et al., Cancer 1998 (Carcinoma, Squamous Cell...) : GM-CSF also increased the MMP activity of LK-2 and LC-1 cells
Zhang et al., J Immunol 1998 : However, GM-CSF , when added with either TNF-alpha or IL-1 beta, induced MMP-1 and synergistically enhanced MMP-9 and TIMP-1