UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to SHC1

CSF2RA — SHC1

Pathways - manually collected, often from reviews:

NCI Pathway Database GMCSF-mediated signaling events: None → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) (modification, collaborate)
Ramshaw et al., Blood 2007
Evidence: mutant phenotype
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) → None (modification, activates) Ramshaw et al., Blood 2007
Evidence: mutant phenotype
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) (modification, collaborate)
Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) (modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) (modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) (modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → None (modification, activates) Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → None (modification, activates) Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) (modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
NCI Pathway Database GMCSF-mediated signaling events: GRB2/GAB2 complex (GRB2-GAB2) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) (modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: SHC (SHC1) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) (modification, collaborate)
Ramshaw et al., Blood 2007
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → SHIP (INPP5D) (modification, collaborate) Ramshaw et al., Blood 2007
Evidence: mutant phenotype, physical interaction
NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) → SHIP (INPP5D) (modification, collaborate) Ramshaw et al., Blood 2007
Evidence: mutant phenotype, physical interaction
Reactome Reaction: CSF2RA → SHC1 (indirect_complex)
Reactome Reaction: CSF2RA → SHC1 (reaction) Gu et al., Mol Cell Biol 2000, Pratt et al., J Biol Chem 1996